Actively Recruiting
Fertility Preservation Using Tamoxifen and Letrozole in Estrogen Sensitive Tumors Trial
Led by University of California, San Francisco · Updated on 2025-05-08
309
Participants Needed
1
Research Sites
505 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Latrogenic infertility as a result of cancer treatment has a profound effect on long-term quality of life in survivors of reproductive-age cancers. Oocyte cryopreservation prior to cancer treatment has been associated with improved quality of life, with a potential ability to reduce long-term decision-related regret in cancer survivors. Though letrozole plus gonadotropin and and tamoxifen plus gonadotropin are currently routinely used worldwide in ovarian stimulation cycles for fertility preservation in patients with estrogen-receptor-positive breast cancer, it is not clear which of the two might lead to improved oocyte yield. Improved knowledge about the efficacy of these medications, with regard to oocyte yield, has the potential to significantly improve quality of life in reproductive-age breast cancer survivors.
CONDITIONS
Official Title
Fertility Preservation Using Tamoxifen and Letrozole in Estrogen Sensitive Tumors Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- New diagnosis of breast cancer
- Has not begun chemotherapy
- Wishes to have ovarian stimulation and oocyte retrieval before cancer treatment
- Age 18 years or older
You will not qualify if you...
- Chemotherapy has already started or been completed
- History of recurrent breast cancer with prior chemotherapy
- Stage IV breast cancer with distant metastases
- Oncologist advises against participation in the trial
- Does not plan to undergo ovarian stimulation and oocyte retrieval before diagnosis
- Significant illness or psychiatric disorder affecting safety or study participation
- Age under 18 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of California at San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
Research Team
R
Rebecca Wong
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here