Actively Recruiting
Fertility Restoration With Autografting of Cryopreserved Immature Testicular Tissue
Led by Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Updated on 2026-04-21
20
Participants Needed
1
Research Sites
623 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a pilot clinical trial to evaluate the feasibility and outcome of autologous transplantation of immature testicular tissue cryopreserved during childhood as a method of fertility preservation for prepubertal boys in case of gonadotoxic therapies. Freezing of immature testicular tissue is performed since the early 2000s and a number of our patients have now reached reproductive age. In case of childwish and azoospermia in adulthood, surgical sperm retrieval is planned and if unsucessful transplantation of the patient's own cryopreserved tissue will be performed during the same surgical intervention as a fertility restoration method.
CONDITIONS
Official Title
Fertility Restoration With Autografting of Cryopreserved Immature Testicular Tissue
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who have completed their gonadotoxic treatment
- Patients who are in good health after treatment of the primary disease based on hemato-oncologist input
- Patients with confirmed azoospermia in adulthood and a desire for children requesting transplantation
- Patients who cryopreserved and stored their immature testicular tissue in compliance with regulatory requirements
- For those with prior hematological malignant disease or metastatic cancer, multidisciplinary assessment must consider the risk of cancer cell contamination negligible
You will not qualify if you...
- Patients whose cryostored tissue presents a non-negligible risk of cancer cell contamination
- Patients with contraindications for general anesthesia
AI-Screening
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Trial Site Locations
Total: 1 location
1
Cliniques universitaires Saint-Luc, Université catholique de Louvain
Brussels, Belgium, 1200
Actively Recruiting
Research Team
C
Christine Wyns, MD, PhD, Full Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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