Actively Recruiting
FES BPET-DBT in Newly Diagnosed Breast Cancer
Led by Abramson Cancer Center at Penn Medicine · Updated on 2026-02-27
20
Participants Needed
1
Research Sites
221 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with newly diagnosed primary estrogen-receptor (ER) positive breast cancer, with at least one breast lesion that is 1.0 cm in diameter or greater, may be eligible for this study. Patients may participate in this study if they are at least 18 years of age. Up to 20 evaluable subjects will participate in a single imaging cohort. Study subjects will undergo imaging of the breast with a novel device combining dedicated Breast Positron Emission Tomography (BPET) and Digital Breast Tomosynthesis (DBT) following intravenous injection of \[18F\]-Fluoroestradiol (FES). This is an observational study; FES-BPET/DBT will not be used to direct treatment decisions. While patients and referring physicians will not be blinded to the FES-BPET/DBT results, treatment decisions are made by the treating physicians based upon standard clinical imaging.
CONDITIONS
Official Title
FES BPET-DBT in Newly Diagnosed Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants will be 18 years of age or older
- Known estrogen receptor positive breast cancer confirmed by immunohistochemistry
- At least one breast lesion 1.0 cm or larger seen on standard imaging such as mammogram, ultrasound, MRI, CT, or FDG-PET/CT
- Willing to provide written informed consent and participate according to institutional and federal guidelines
You will not qualify if you...
- Pregnant or breastfeeding females; urine pregnancy test required for women of child-bearing potential before PET imaging
- Unable to tolerate imaging procedures as determined by an investigator or treating physician
- Currently taking tamoxifen or raloxifene
- Any current medical condition or illness that could compromise safety or study participation as assessed by a physician investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19130
Actively Recruiting
Research Team
E
Erin o Schubert
CONTACT
H
Hannah Straughn
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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