Actively Recruiting
FET PET in Differentiating Tumour Progression From Pseudoprogression in High Grade Glioma
Led by Singapore General Hospital · Updated on 2024-12-03
22
Participants Needed
2
Research Sites
114 weeks
Total Duration
On this page
Sponsors
S
Singapore General Hospital
Lead Sponsor
N
National Cancer Centre, Singapore
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate the performance characteristics of O-(2-\[18F\]fluoroethyl)-L-tyrosine (FET) PET in differentiating pseudoprogression from tumour progression in patients with equivocal conventional imaging and determine the sensitivity and specificity of \[18F\]FET-PET in delineating disease. The main question\[s\] it aims to answer are: * whether 18F-FET-PET will demonstrate high diagnostic accuracy to detect true tumour progression * whether we can optimise the threshold cut-offs for TBRmax and other relevant parameters in discriminating pseudoprogression and disease progression Participants will undergo a limited 18F-FET PET/CT of the brain in SGH.
CONDITIONS
Official Title
FET PET in Differentiating Tumour Progression From Pseudoprogression in High Grade Glioma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men or women aged 21 years or older at time of screening
- Histologically confirmed malignant glioma (WHO grade III or IV) with prior radiation therapy to the tumour
- Presence of enlarging contrast-enhancing and/or T2W/FLAIR-hyperintense lesion(s) on MRI within previous radiation field
- Gliomas with IDH wild-type status confirmed by immunohistochemistry
- Willingness to consent and undergo all study procedures
You will not qualify if you...
- Low-grade gliomas (WHO grade 1 or 2)
- Previous treatment with bevacizumab, VEGF-targeting agents, or other anti-angiogenic therapies
- Proven cerebral metastases
- IDH-mutated gliomas
- Pregnancy or breastfeeding
AI-Screening
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Trial Site Locations
Total: 2 locations
1
National Cancer Centre Singapore
Singapore, Singapore
Actively Recruiting
2
Singapore General Hospital
Singapore, Singapore
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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