Study of CCR Receptor Overexpression in Fetal Microchimeric Cells Proof of Concept Before a Potential Clinical Trial

What this Trial Is About

Researchers are studying the presence and behavior of foetal cells in post-partum women, focusing on their role in wound healing. The study aims to describe the gene expression profiles of these foetal cells, particularly looking at which chemokine receptors are more active in women who have wounds compared to healthy post-partum women. This approach supports the concept of using natural foetal stem cells for healing, which may avoid some risks linked to other stem cell therapies. Participants include post-partum women with venous, diabetic, sickle cell, or mixed skin ulcers, as well as age-matched post-partum women without wounds serving as controls. The study involves collecting blood and saliva samples to isolate foetal cells and perform detailed RNA sequencing to analyze their gene activity. Clinical examinations and interviews are also conducted during study visits to gather additional information. Throughout the study, researchers will analyze the isolated foetal cells using advanced sequencing techniques to understand their transcriptomic profiles. The main outcome is the single-cell transcriptomic analysis conducted over the first five months. Participants will be monitored through clinical exams and interviews, and their samples processed to identify key chemokine receptors that could guide future treatments. The study participation may last several months, with follow-up assessments as needed.

Fetal Cell Receptors Repertoire