Actively Recruiting
Fetal Fornix and Hippocampus in Pregnant Women With Early-Onset Preeclampsia
Led by Ankara Etlik City Hospital · Updated on 2025-12-23
84
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Since early-onset preeclampsia (EOPE) is commonly associated with inadequate placentation, placental insufficiency, chronic fetal hypoxia, oxidative stress, and heightened inflammation, these pathological processes may adversely affect hippocampal neuronal development and maturation of axonal pathways such as the fornix. These mechanisms support our hypothesis that fetal fornix and hippocampus dimensions may be reduced in pregnancies complicated by EOPE, forming the scientific basis of our study. Previous research has suggested a potential link between preeclampsia (PE) and altered neurocognitive development. However, no studies to date have specifically evaluated the relationship between EOPE and fetal fornix or hippocampus dimensions. Therefore, the objective of our study is to assess fetal fornix and hippocampus measurements in pregnant women with early-onset preeclampsia compared with healthy controls.
CONDITIONS
Official Title
Fetal Fornix and Hippocampus in Pregnant Women With Early-Onset Preeclampsia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18-45 years
- Gestational age between 20 and 34 weeks
- Diagnosis of early-onset preeclampsia (EOPE)
- Singleton pregnancy
You will not qualify if you...
- Multiple pregnancies
- Presence of chronic or significant comorbid conditions other than maternal early-onset preeclampsia, including chronic, mental, or physical illnesses, severe renal, hepatic, or gastrointestinal acute or chronic inflammatory diseases, hyperthyroidism or hypothyroidism, chronic hypertension, type 1 or type 2 diabetes mellitus, history of polycystic ovary syndrome (PCOS), history of malignancy
- Fetal congenital or chromosomal anomalies
- Chronic medication use
- Tobacco or alcohol use during pregnancy
- Maternal late-onset preeclampsia (≥34 weeks gestation)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ankara Etlik City Hospital
Ankara, Yenimahalle, Turkey (Türkiye), 06170
Actively Recruiting
Research Team
S
Seyit A Erol, MD
CONTACT
K
Kadriye Yakut Yucel, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here