Actively Recruiting
The Fever Clinic Acute Respiratory Cohort (FACTS): A Prospective Real-World Study of Clinical Features, Laboratory and Radiographic Findings, and Outcomes of Acute Respiratory Infections
Led by Fudan University · Updated on 2025-12-12
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
F
Fudan University
Lead Sponsor
H
Huadong Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the natural progression and outcomes of acute respiratory infections in patients who visit fever clinics. This observational cohort study aims to collect detailed clinical symptoms, laboratory results, and chest imaging data at enrollment. The research focuses on understanding disease progression, complications, and long-term results without introducing any new treatments, allowing all patients to receive routine care as directed by their doctors. Participants will be followed over time to observe how their illness develops and resolves. No interventions are involved since this is an observational study. Data such as symptom changes, laboratory markers, and imaging findings will be gathered at various points. This design helps to identify factors affecting clinical outcomes in a real-world setting. During the study, participants' symptoms, lab tests, and imaging will be regularly assessed. Researchers will track hospitalization rates for pneumonia within 30 days, symptom resolution at 24 hours and 7 days, ICU admissions, mortality rates, and changes in blood markers like white blood cell count and C-reactive protein. Follow-up includes monitoring unplanned medical visits and exacerbations of chronic diseases. The total study period extends through long-term observation, with all data collected to better understand acute respiratory infections.
CONDITIONS
Brief Title
The Fever Clinic Acute Respiratory Cohort
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Fever at the time of visit or within 24 hours prior, defined by specific temperature thresholds
- Fever primarily caused by a respiratory tract infection as determined by a physician
- Blood draw required as part of standard clinical care
- Ability to understand the study and provide written informed consent
You will not qualify if you...
- Unable to provide informed consent due to impaired consciousness or other reasons
- Inability to comply with study procedures
- Medical contraindications to blood sampling such as severe coagulopathy (INR > 3.0, platelet count < 50 × 10⁹/L)
- Diagnosed with a terminal illness with life expectancy less than 3 months, such as advanced cancer or severe multiple organ failure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Baseline visit
Participants undergo clinical symptom assessment, laboratory tests, and chest imaging to characterize acute respiratory infection.
1 visit (in-person)
Duration - Up to 30 days
Participants are followed over time to assess disease progression, complications, and outcomes under routine clinical care.
Follow-up visits as part of standard care, timing may vary
Trial Site Locations
Total: 1 location
1
Huadong hospital
Shanghai, Shanghai Municipality, China, 200040
Actively Recruiting
Research Team
Y
YingGang Zhu, Doctor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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