Actively Recruiting
Fexofenadine in Patients With Active Rheumatoid Arthritis
Led by October 6 University · Updated on 2025-07-31
80
Participants Needed
2
Research Sites
187 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Rheumatoid arthritis (RA) is an inflammatory autoimmune polyarthritis affecting ∼1% of the world population, resulting in the loss of joint function and progressive structural damage in affected joints. Fexofenadine has been widely used to treat various allergic diseases, like allergic rhinitis, conjunctivitis and chronic idiopathic urticaria. the molecular mechanisms underlying fexofenadine mediated inhibition of TNF-α signalling
CONDITIONS
Official Title
Fexofenadine in Patients With Active Rheumatoid Arthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Moderate to severe rheumatoid arthritis with disease activity score-28 joints (DAS-28) > 3.2
- Age between 18 and 60 years with active disease diagnosed by an experienced rheumatologist
- Currently treated with disease-modifying anti-rheumatic drugs (DMARDs), not receiving cytokine inhibitors
- Signed informed consent and willingness to accept randomization to any treatment arm
You will not qualify if you...
- History of biological DMARDs use
- Presence or history of acute heart disease, liver disease, kidney disease, or COPD
- Allergy or intolerance to fexofenadine or methotrexate
- Alcohol abuse
- Recent changes in medication dosage or type
- Current use of hormone replacement therapy, warfarin, or other anticoagulants
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Beni-Suef Hospital
Banī Suwayf, Egypt
Actively Recruiting
2
Faculty of Medicine - Beni Suef Hospital
Banī Suwayf, Egypt
Actively Recruiting
Research Team
A
Ahmed Ismaeel
CONTACT
E
Engy Wahsh
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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