Actively Recruiting
Fiber and Calcium Absorption in Older Men
Led by VA Office of Research and Development · Updated on 2026-02-17
30
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
Sponsors
V
VA Office of Research and Development
Lead Sponsor
S
San Francisco VA Health Care System
Collaborating Sponsor
AI-Summary
What this Trial Is About
Osteoporotic fractures are a major but underrecognized problem in men. There is growing evidence that low dietary fiber intake is a modifiable risk factor for age-related bone loss in men. Preclinical and human studies in adolescents and postmenopausal women suggest that dietary fiber intake influences bone metabolism by modulating the gut microbiome to augment intestinal calcium absorption, but it is unclear through what molecular mechanism and whether dietary fiber has the same effects in older men. In this crossover intervention study, the investigators will enroll and follow 30 older male Veterans to evaluate the effects of soluble corn fiber on intestinal calcium absorption and explore the contribution of the gut microbiome.
CONDITIONS
Official Title
Fiber and Calcium Absorption in Older Men
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male Veterans 60 years of age
You will not qualify if you...
- History of malabsorption
- Hypercalcemia (corrected Ca > 10.2 mg/dL)
- Vitamin D insufficiency (25OHD < 30 ng/mL)
- Chronic kidney disease stage 3B or worse (CrCl < 45 mL/min)
- Severe hypogonadism (AM fasting serum total testosterone < 150 ng/dL)
- Daily use of proton pump inhibitor
- Use of medication(s) known to affect calcium metabolism
- Use of medications or supplements that could impact gut microbiota in the previous 3 months (antibiotics or commercially available probiotics or prebiotics)
- Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
San Francisco VA Medical Center, San Francisco, CA
San Francisco, California, United States, 94121-1563
Actively Recruiting
Research Team
K
Karin C Wu, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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