Study of Potato Starch Fiber Supplement to Boost Short Chain Fatty Acids in Adults with Type 2 Diabetes and Heart Failure with Preserved Ejection Fraction

What this Trial Is About

Researchers are studying how increasing dietary fiber by adding potato starch to the diet may affect the types of bacteria in the gut microbiome of people with stable Heart Failure With Preserved Ejection Fraction HFpEF and Type II diabetes. They also want to see if this supplement helps these bacteria produce more short chain fatty acids, which might benefit health. Participants will take a potato starch supplement for about 4 weeks. They will start by consuming 10 grams twice a day for the first week, then increase to 20 grams daily for approximately 3 weeks. The potato starch can be mixed into cold food or drinks. During the study, participants will have evaluations and provide blood and stool samples. Throughout the study, researchers will measure changes in short chain fatty acid levels, including butyrate, propionate, and acetate, in stool and plasma samples at the start and after about 4 weeks. The study is sponsored by the University of Michigan and no masking or blinding is used. Participants will be monitored for health and safety during the treatment period.

Fiber Supplementation in Heart Failure With Preserved Ejection Fraction (HFpEF)