Actively Recruiting
Fibrin-Enhanced TIP Versus Grafted TIP Urethroplasty in Distal Hypospadias
Led by National Children's Medical Center, Uzbekistan · Updated on 2026-01-30
100
Participants Needed
2
Research Sites
155 weeks
Total Duration
On this page
Sponsors
N
National Children's Medical Center, Uzbekistan
Lead Sponsor
D
Dr Cipto Mangunkusumo General Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Hypospadias is a common congenital condition in boys in which the opening of the urethra is located on the underside of the penis. Distal hypospadias is the most common form and is usually treated surgically using tubularized incised plate (TIP) urethroplasty. In boys with an unfavorable urethral plate, graft-augmented techniques (G-TIP) are often used; however, postoperative complications such as urethrocutaneous fistula and narrowing of the urethral opening (meatal stenosis) may still occur. Platelet-rich fibrin (PRF) is a biological material obtained from the patient's own blood that contains natural growth factors and may help improve tissue healing. This study aims to evaluate whether the use of PRF during surgery can reduce postoperative complications and improve surgical outcomes in children undergoing hypospadias repair.
CONDITIONS
Official Title
Fibrin-Enhanced TIP Versus Grafted TIP Urethroplasty in Distal Hypospadias
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male children aged 6 months to 84 months
- Primary or redo distal hypospadias
- Unfavorable urethral plate
- Penile curvature less than 45 degrees after degloving
- Eligible for tubularized incised plate urethroplasty
You will not qualify if you...
- Disorders of sex development or ambiguous genitalia
- Severe penile curvature requiring urethral plate transection
- Previous graft-based urethroplasty
- Active local or systemic infection at the time of surgery
- Known bleeding or platelet disorders
- Inability to comply with postoperative follow-up
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Dr. Cipto Mangunkusumo Hospital
Jakarta, DKI Jakarta, Indonesia, 10430
Not Yet Recruiting
2
National Children's Medical Center
Tashkent, Tashkent, Uzbekistan, 100020
Actively Recruiting
Research Team
Z
Zafar Abdullaev, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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