Study of Small Fiber Neuropathy in Adults with Fibromyalgia and Other Chronic Pains

What this Trial Is About

Researchers are evaluating the presence of small fiber neuropathy in patients with fibromyalgia compared to those with other types of chronic pain and healthy individuals. The study aims to better understand the role of small nerve fiber abnormalities in fibromyalgia symptoms and pain. This observational study will use structural and functional tests to explore the characteristics and impact of small fiber neuropathy in these groups. Participants will undergo skin punch biopsies to measure nerve fiber density and several functional tests including quantitative sensory testing, laser evoked potentials, Sudoscan, and confocal corneal microscopy. The study includes three groups fibromyalgia patients, patients with other chronic pain types, and healthy controls matched by age and gender. These assessments will be done at the start and after six months to monitor changes. During the study, participants will be evaluated through clinical examinations, skin biopsies, and multiple sensory and nerve function tests. Researchers will measure the prevalence of small fiber neuropathy, correlate nerve fiber density with pain and quality of life, and assess the diagnostic value of various tests. The study will last at least six months and includes ongoing monitoring of symptoms and nerve function over time.

Fibromyalgia and Small Fiber Neuropathy