Actively Recruiting
Fibrosis in Chronic and Delayed Myocardial Infarction
Led by University of Edinburgh · Updated on 2026-01-09
180
Participants Needed
1
Research Sites
303 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this study the investigators aim to examine the role that fibrosis plays in heart conditions such as aortic stenosis , chemotherapy-induced cardiotoxicity and carcinoid syndrome . Fibrosis is a common final result following any injury to the heart muscle and the investigators aim to identify this process early and in its active state. This will be examined by using a radiotracer 68Ga-FAPI or 18F-AlF-FAPI and PET-MRI or PET-CT.
CONDITIONS
Official Title
Fibrosis in Chronic and Delayed Myocardial Infarction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 50 years or older for aortic stenosis cohort
- Adults over 35 years old for chemotherapy-induced cardiotoxicity and carcinoid syndrome cohorts
- Ability to provide informed consent before any study procedures
- Patients with symptomatic severe aortic stenosis (peak velocity > 4.0 m/s)
- Patients with moderate aortic stenosis (peak velocity 3.0-4.0 m/s)
- Patients with mild aortic stenosis (peak velocity 2.6-2.9 m/s)
- Patients with aortic sclerosis (thickened tri-leaflet aortic valve without obstruction)
- Healthy volunteers without significant co-morbidities as assessed by the study investigator
- Patients with evidence of cardiotoxicity on cardiac MRI at least 1 year after anthracycline treatment
- Patients without evidence of fibrosis on 1-year scan after anthracycline treatment
- Patients diagnosed with carcinoid syndrome, with or without cardiac involvement, as per guidelines
You will not qualify if you...
- Unable or unwilling to provide informed consent
- History of claustrophobia or inability to tolerate lying flat for MRI scans
- Impaired kidney function with estimated glomerular filtration rate below 30 mL/min/1.73m2
- Pregnant or breastfeeding women
- Allergy to contrast agents
- Contraindications to cardiac MRI such as metallic implants or severe claustrophobia
- Recent myocardial infarction or other known causes of cardiomyopathy or cardiac fibrosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Edinburgh
Edinburgh, Scotland, United Kingdom, NE7 7EY
Actively Recruiting
Research Team
K
Krithika Loganath, MBBS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here