Actively Recruiting
Filter Lifespan in Continuous Renal Replacement Therapy
Led by University Hospital Muenster · Updated on 2024-12-12
600
Participants Needed
5
Research Sites
126 weeks
Total Duration
On this page
Sponsors
U
University Hospital Muenster
Lead Sponsor
B
Baxter Healthcare Corporation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The only supportive therapy for patients with AKI is renal replacement therapy (RRT). In the ICU setting, continuous RRT (CRRT) is mostly favored. In a post-hoc analysis of the RICH trial (regional citrate versus systemic heparin anticoagulation for CRRT in critically ill patient with AKI), it was shown that the filter life span is associated with an increased rate of new infection and that the type of anticoagulants did not directly affect infection rate. The mechanisms of this infection rate is unknown.
CONDITIONS
Official Title
Filter Lifespan in Continuous Renal Replacement Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 years or older
- Critically ill patients with dialysis-dependent acute kidney injury
- Receiving continuous renal replacement therapy (CRRT)
- Able to provide written informed consent
You will not qualify if you...
- Chronic kidney disease with estimated glomerular filtration rate (eGFR) below 30 ml/min/1.73m2
- Dependence on chronic dialysis
- History of kidney transplant
- Diagnosed with (glomerulo-)nephritis, interstitial nephritis, or vasculitis
- Currently on immunosuppressive therapy
- Presence of chronic inflammatory diseases such as arthritis, HIV, or chronic hepatitis
- Employment by or dependency on the study investigator or sponsor
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Univ.-Klinik Innsbruck
Innsbruck, Austria
Actively Recruiting
2
Universidade de São Paulo
São Paulo, Brazil
Actively Recruiting
3
Universitätsklinikum Erlangen-Nürnberg, Abteilung für Nephrologie und Hypertensiologie
Erlangen, Germany, 91054
Actively Recruiting
4
Kliniken Maria Hilf, Klinik für Anästhesiologie und Operative Intensivmedizin
Mönchengladbach, Germany, 41063
Actively Recruiting
5
University Hospital Muenster
Münster, Germany, D-48149
Actively Recruiting
Research Team
A
Alexander Zarbock, MD
CONTACT
M
Melanie Meersch-Dini, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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