Finnish Discectomy Trial Comparing Microdiscectomy Surgery to Placebo Surgery for Adults With Sciatica Caused by Lumbar Disc Herniation

What this Trial Is About

Researchers are studying whether microdiscectomy, a common back surgery, is effective and safe for treating sciatica caused by a lumbar disc herniation. The trial focuses on adults aged 18 to 60 whose leg pain has not improved after at least six weeks of non-surgical treatment. It aims to provide clear evidence comparing real surgery to placebo surgery to help patients and doctors make informed decisions. Participants are randomly assigned to receive either the actual microdiscectomy surgery, which involves removing herniated disc material through a surgical approach, or a placebo surgery that mimics the procedure without removing any disc material or bone. Only the surgical team knows which procedure was performed patients and most healthcare staff do not. Both groups receive standard post-operative care at specialized spine centers. Throughout the study, participants will be monitored for pain levels, symptom improvement, disability, quality of life, and any adverse events. Assessments occur before surgery and at several points up to one year after the procedure. An independent board oversees safety, and data are securely collected by blinded staff. The study includes thorough follow-up to compare outcomes between real and placebo surgery over time.

FINDISC-Pain, Finnish Discectomy Trial on the Benefits and Harms of Surgery in Patients With Lumbar Disc Herniation