Actively Recruiting
A First-ever Research Collaboration to Characterize MRI Measured Neural Flexibility Development in Chinese Toddlers
Led by Société des Produits Nestlé (SPN) · Updated on 2025-12-03
60
Participants Needed
1
Research Sites
147 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overall objective is to characterize the developmental characteristics of MRI measured neural flexibility, as an index of cognitive flexibility, in Chinese toddlers (32 to 42 months old).
CONDITIONS
Official Title
A First-ever Research Collaboration to Characterize MRI Measured Neural Flexibility Development in Chinese Toddlers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent has been obtained from the parent/legally acceptable representative.
- Full-term birth (≥ 37 weeks and ≥ 2.5kg).
- Typically developing children aged between 32-34 months (2 years 8 months to 2 years 10 months) at enrolment.
- Neurotypical development as assessed by interview.
- No major risk factors for learning, neurologic, or psychiatric disorder as assessed by interview (defined as a diagnosed learning, neurologic or psychiatric disorder in a first degree relative such as parents or siblings).
- For S-26 GOLD or ULTIMA GUM-fed group: daily consumption of S-26 GOLD or ULTIMA GUM for the last 60 days (2 months) and parental desire to continue feeding GUM during the study.
- For cow's milk-fed group: daily consumption of cow's milk for the last 60 days (2 months) and parental desire to continue feeding cow's milk during the study.
You will not qualify if you...
- Delayed birth (> 41 weeks gestation) as reported in medical record.
- Birth weight < 2500 g or small for gestational age (below the 10th percentile) or large for gestational age (above the 90th percentile) as reported in medical record.
- History of neurological (e.g., head injury, epilepsy), psychiatric, or developmental disorder in the toddler as assessed by interview.
- History of diagnosed neurological, psychiatric, or developmental disorder in parents or siblings as assessed by interview.
- In utero exposure to alcohol abuse or illicit substances as defined by diagnosis of current substance use disorder in the biological mother and relevant medical guidelines.
- Multiple birth as reported in medical record.
- Complicated pregnancy (e.g., preeclampsia, gestational diabetes) as assessed by medical interview or record.
- Abnormal screening laboratory values or studies considered clinically significant by the Investigator (e.g., metabolic disease screening, neonatal bilirubin).
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Shanghai Children's Medical Center
Shanghai, Shanghai Municipality, China
Actively Recruiting
Research Team
J
Joyce Li
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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