Actively Recruiting

Age: 0 - 11Years
All Genders
Healthy Volunteers
NCT06263868

First Observatory of Precocious Puberty.

Led by Hospices Civils de Lyon · Updated on 2026-01-16

3360

Participants Needed

25

Research Sites

208 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The age of puberty has fluctuated throughout history. Recent data shows an increase in the age of onset of puberty signs, in the United States but also in Europe. A recent Public Health France study published in 2018 reports an increase in the incidence of precocious puberty with geographical heterogeneity. The consequences of these appearances include the early onset of menarche, short adult height and the psychological impact. Due to a lack of studies and additional data, the reasons for this development are difficult to understand. Among current hypotheses, the entanglement with the evolution of our environment is at the forefront: the action of environmental endocrine disruptors and nutritional factors could play a role in the process of early appearance of pubertal signs. The establishment of a national observatory for early and advanced puberty in collaboration with pediatric endocrinologists (on the front line) would allow a reliable and precise field approach, capable of supplementing epidemiological data, which are currently insufficient. The investigators hypothesize that the establishment of an observatory of pubertal advances (early puberty and advanced puberty) in private medicine is possible, with inclusion of at least 75% of eligible patients, and collection of at least 80% of data.

CONDITIONS

Official Title

First Observatory of Precocious Puberty.

Who Can Participate

Age: 0 - 11Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Suspected precocious puberty (girl under 8 years or boy under 9 years with first signs of development)
  • Suspected advanced puberty (girl aged 8 to under 10 years or boy aged 9 to under 11 years with first signs of development)
  • First consultation with the pediatric endocrinologist investigator
  • Control group: boy or girl without pubertal signs (Tanner 1), matched by sex and age (+/- 1 year), consulting the same investigator in the same quarter as a PP group patient
Not Eligible

You will not qualify if you...

  • Families with a language barrier or who do not speak French
  • Consultation with the same investigator in the same quarter as a patient in the PP group (applies to all groups)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 25 locations

1

Clinique du Val d'Ouest

Écully, Auvergne-Rhône-Alpes, France, 69130

Actively Recruiting

2

Clinique du Val d'Ouest

Écully, Auvergne-Rhône-Alpes, France, 69130

Actively Recruiting

3

Clinique du Val d'Ouest

Écully, Auvergne-Rhône-Alpes, France, 69130

Actively Recruiting

4

Pediatric practice

Lyon, Auvergne-Rhône-Alpes, France, 69006

Actively Recruiting

5

Pediatric practice

Rennes, Brittany Region, France, 35200

Actively Recruiting

6

Pediatric practice

Chambray-lès-Tours, Centre-Val de Loire, France, 37170

Actively Recruiting

7

Pediatric practice

Essey-lès-Nancy, Grand Est, France, 54270

Actively Recruiting

8

Pediatric practice

Levallois-Perret, Hauts-de-Seine, France, 92300

Active, Not Recruiting

9

Pediatric practice

Fondettes, Indre-et-Loire, France, 37230

Actively Recruiting

10

Polyclinique Bordeaux rive droite

Lormont, New Aquitaine, France, 33310

Active, Not Recruiting

11

Pediatric practice

Pau, New Aquitaine, France, 64000

Actively Recruiting

12

Pediatric Practice

Pessac, New Aquitaine, France, 33600

Actively Recruiting

13

Clinique rive gauche

Toulouse, Occitanie, France, 31300

Not Yet Recruiting

14

Pediatric practice

Saint-Nazaire, Pays de la Loire Region, France, 44600

Not Yet Recruiting

15

Pediatric practice

Aix-en-Provence, France, 13090

Actively Recruiting

16

Hôpital Femme Mère Enfant, Hospices civils de Lyon

Bron, France, 69677

Actively Recruiting

17

Pediatric practice

Marseille, France, 13008

Active, Not Recruiting

18

Pediatric practice

Marseille, France, 13012

Actively Recruiting

19

Pediatric practice

Nice, France, 06000

Actively Recruiting

20

Clinique Saint jean

Saint-Jean-de-Védas, France, 34430

Active, Not Recruiting

21

Pediatric practice

Trélazé, France, 49800

Actively Recruiting

22

Pediatric practice

Paris, Île-de-France Region, France, 75010

Actively Recruiting

23

Pediatric practice

Paris, Île-de-France Region, France, 75011

Actively Recruiting

24

Pediatric practice

Paris, Île-de-France Region, France, 75017

Actively Recruiting

25

Pediatric practice

Paris, Île-de-France Region, France, 75116

Active, Not Recruiting

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Research Team

E

Emillie Doye, MD

CONTACT

T

Tiphanie GINHOUX

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

3

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First Observatory of Precocious Puberty. | DecenTrialz