Actively Recruiting
Fish Oil, Metformin and Heart Health in PCOS
Led by University of Alberta · Updated on 2025-12-12
146
Participants Needed
3
Research Sites
112 weeks
Total Duration
On this page
Sponsors
U
University of Alberta
Lead Sponsor
H
Heart and Stroke Foundation of Canada
Collaborating Sponsor
AI-Summary
What this Trial Is About
Women with Polycystic Ovary Syndrome (PCOS) have high testosterone levels which is associated with altered insulin-glucose metabolism and an adverse blood lipid profile, predisposing them to the development of Type II Diabetes and Cardiovascular Disease (CVD). This study will investigate the use of dietary fish oil supplementation as a safe and effective intervention, and as an adjunct therapy to standard of care treatment with metformin to improve heart health, blood lipids and insulin-glucose metabolism in women with PCOS, and those with PCOS and Type 2 Diabetes.
CONDITIONS
Official Title
Fish Oil, Metformin and Heart Health in PCOS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Polycystic Ovary Syndrome (PCOS)
- Overweight or obese with a body mass index (BMI) over 25 kg/m2
- Elevated fasting plasma triglycerides greater than 150 mg/dL
- Elevated apoB48-remnant cholesterol lipoproteins above 20 ug/ml
- Impaired insulin sensitivity with fasting glucose 100-125 mg/dL and/or insulin greater than 15 uM/ml
- May have type 2 diabetes with blood glucose over 126 mg/dL
You will not qualify if you...
- Pregnancy
- Lactation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Human Nutrition Research Unit - Li Ka Shing Health Research Center
Edmonton, Alberta, Canada, T6G 2E1
Actively Recruiting
2
Mazankowski Alberta Heart Institute
Edmonton, Alberta, Canada, T6G-2B7
Actively Recruiting
3
University of Alberta Hospital - Division of Endocrinology
Edmonton, Alberta, Canada, T6G-2B7
Actively Recruiting
Research Team
D
Donna Vine, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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