Actively Recruiting

Phase Not Applicable
Age: 60Years +
All Genders
NCT05100966

FitJoints: Getting Fit for Hip and Knee Replacement

Led by McMaster University · Updated on 2025-07-01

192

Participants Needed

4

Research Sites

193 weeks

Total Duration

On this page

Sponsors

M

McMaster University

Lead Sponsor

H

Hamilton Health Sciences Corporation

Collaborating Sponsor

AI-Summary

What this Trial Is About

Total hip or knee replacement is an important and cost-effective surgical intervention to relieve pain and improve independence and function in patients with osteoarthritis. The number of people waiting for elective surgeries has spiked in the COVID-19 pandemic. Prior to COVID-19, up to 40% of patients receiving joint replacement were frail and this number is rapidly increasing with longer wait-times and deconditioning associated with COVID-19 physical distancing. There is an urgent need to be responsive to the evolving challenges of healthcare. The proposed study is the first multi-site randomized controlled trial (RCT) to examine whether a multimodal frailty reduction intervention before surgery will improve postsurgical outcomes for this population. The COVID-19 adapted hybrid model includes a multimodal frailty intervention that may be implemented either in person or virtually and is aligned with international consensus guidelines on frailty reduction. To utilize the FitJoints multimodal frailty intervention to build resilience of patients undergoing joint replacement surgery to improve post-operative outcomes. The investigators hypothesize the FitJoints multimodal frailty intervention, with exercise, nutrition and medication optimization, will reduce frailty and pain while improving function and quality of life. Building upon the success of the FitJoints feasibility study (n=69) in Hamilton, Ontario, in the proposed multi-site RCT (n=192), older adults (≥60 years) undergoing hip or knee joint replacement surgery who are frail will be randomized to either the 3 to 6-months of multimodal intervention or usual care until the date of their surgery at multiple sites (Hamilton Health Sciences \& St Joseph's Healthcare Hamilton, ON; London Health Science Centre, London, ON; Foothills Hospital, Calgary, AB),The FitJoints evidence-based, multimodal intervention includes a hybrid model that can be implemented either in person or virtually: 1. Physiotherapist supported multi-component exercise program 2. Nutrition and protein optimization including dietary counseling 3. Medication review with prescribing recommendations

CONDITIONS

Official Title

FitJoints: Getting Fit for Hip and Knee Replacement

Who Can Participate

Age: 60Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Pre-frail (score of 1 or 2) or frail (score of 3-5)
  • 60 years of age or older
  • Scheduled for elective unilateral total hip or knee replacement surgery
  • Estimated waiting time for surgery is between 4 to 15 months
Not Eligible

You will not qualify if you...

  • Kidney (renal) disorder
  • Neuromuscular disorder
  • Active cancer
  • Inflammatory arthritis
  • Unable to speak or understand English without a caregiver for translation
  • Participating in another trial involving protein supplementation
  • Currently participating in an exercise program

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 4 locations

1

Foothill Medical Centre - Alberta Health Services

Calgary, Alberta, Canada

Not Yet Recruiting

2

Juravinski Hospital - Hamilton Health Sciences

Hamilton, Ontario, Canada

Actively Recruiting

3

St. Joseph's Healthcare

Hamilton, Ontario, Canada

Not Yet Recruiting

4

University Hospital - London Health Sciences Centre

London, Ontario, Canada

Not Yet Recruiting

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Research Team

A

Alexandra Papaioannou, MD, MSc

CONTACT

G

George Ioannidis, MSc, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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