Actively Recruiting
FitJoints: Getting Fit for Hip and Knee Replacement
Led by McMaster University · Updated on 2025-07-01
192
Participants Needed
4
Research Sites
193 weeks
Total Duration
On this page
Sponsors
M
McMaster University
Lead Sponsor
H
Hamilton Health Sciences Corporation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Total hip or knee replacement is an important and cost-effective surgical intervention to relieve pain and improve independence and function in patients with osteoarthritis. The number of people waiting for elective surgeries has spiked in the COVID-19 pandemic. Prior to COVID-19, up to 40% of patients receiving joint replacement were frail and this number is rapidly increasing with longer wait-times and deconditioning associated with COVID-19 physical distancing. There is an urgent need to be responsive to the evolving challenges of healthcare. The proposed study is the first multi-site randomized controlled trial (RCT) to examine whether a multimodal frailty reduction intervention before surgery will improve postsurgical outcomes for this population. The COVID-19 adapted hybrid model includes a multimodal frailty intervention that may be implemented either in person or virtually and is aligned with international consensus guidelines on frailty reduction. To utilize the FitJoints multimodal frailty intervention to build resilience of patients undergoing joint replacement surgery to improve post-operative outcomes. The investigators hypothesize the FitJoints multimodal frailty intervention, with exercise, nutrition and medication optimization, will reduce frailty and pain while improving function and quality of life. Building upon the success of the FitJoints feasibility study (n=69) in Hamilton, Ontario, in the proposed multi-site RCT (n=192), older adults (≥60 years) undergoing hip or knee joint replacement surgery who are frail will be randomized to either the 3 to 6-months of multimodal intervention or usual care until the date of their surgery at multiple sites (Hamilton Health Sciences \& St Joseph's Healthcare Hamilton, ON; London Health Science Centre, London, ON; Foothills Hospital, Calgary, AB),The FitJoints evidence-based, multimodal intervention includes a hybrid model that can be implemented either in person or virtually: 1. Physiotherapist supported multi-component exercise program 2. Nutrition and protein optimization including dietary counseling 3. Medication review with prescribing recommendations
CONDITIONS
Official Title
FitJoints: Getting Fit for Hip and Knee Replacement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pre-frail (score of 1 or 2) or frail (score of 3-5)
- 60 years of age or older
- Scheduled for elective unilateral total hip or knee replacement surgery
- Estimated waiting time for surgery is between 4 to 15 months
You will not qualify if you...
- Kidney (renal) disorder
- Neuromuscular disorder
- Active cancer
- Inflammatory arthritis
- Unable to speak or understand English without a caregiver for translation
- Participating in another trial involving protein supplementation
- Currently participating in an exercise program
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Foothill Medical Centre - Alberta Health Services
Calgary, Alberta, Canada
Not Yet Recruiting
2
Juravinski Hospital - Hamilton Health Sciences
Hamilton, Ontario, Canada
Actively Recruiting
3
St. Joseph's Healthcare
Hamilton, Ontario, Canada
Not Yet Recruiting
4
University Hospital - London Health Sciences Centre
London, Ontario, Canada
Not Yet Recruiting
Research Team
A
Alexandra Papaioannou, MD, MSc
CONTACT
G
George Ioannidis, MSc, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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