Study of Fitness and Lung Health in Young People with Heart Transplant, Leukemia, or Chronic Lung Disease of Prematurity Including Exercise Testing and Physical Activity Assessment

What this Trial Is About

Researchers are studying exercise intolerance and the ability to assess heart and lung function and exercise capacity in young people with chronic childhood diseases. The conditions included are acute lymphoblastic leukemia survivors, chronic lung disease of prematurity, and those who have had a heart transplant. The goal is to better understand exercise limitations and help guide future exercise recommendations for this growing population as they age into adulthood. Participants include adolescents and young adults from 8 to 25 years old, including healthy controls for comparison. The study involves one visit lasting 3 to 4 hours during which participants undergo exercise testing to measure peak oxygen intake and heart function. Participants also provide information about their physical activity and perceived fitness. Both cases and healthy controls are ambulatory and meet specific health criteria. During the visit, researchers measure lung function, cardiac output, and exercise capacity using non-invasive testing. They also assess expiratory flow limitation and link heart function to patient-reported fitness levels. The study uses questionnaires completed on paper or electronically to gather activity data. The researchers aim to collect detailed data in a single visit to better characterize exercise capacity and limitations in these groups.

Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise