Actively Recruiting
Flap Sparing in Postoperative Radiotherapy of Oral Cavity Cancers
Led by Centre Francois Baclesse · Updated on 2026-03-03
348
Participants Needed
25
Research Sites
469 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with oral cavity cancer treated by reconstructive surgery with a flap. Patients will be treated in the study for : * Experimental arm: Post-operative radiotherapy with flap sparing * Control arm: Standard post-operative radiotherapy without flap sparing (current practice) Radiotherapy by IMRT using photons or proton therapy (IMPT)
CONDITIONS
Official Title
Flap Sparing in Postoperative Radiotherapy of Oral Cavity Cancers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient aged 18 years or older
- Performance Status 0-2
- Diagnosis of oral cavity cancer (soft tissue or soft tissue-bone flap) treated by reconstructive surgery with a flap; or oropharynx cancer with flap extending into the oral cavity
- Quality of surgical resection with margins greater than 1 mm
- Candidate for post-operative radiotherapy using IMRT or proton therapy
- Concomitant chemotherapy allowed
- Signed written informed consent before trial procedures
- Affiliated to the social security system
You will not qualify if you...
- Local flap of small size limiting IMRT modulation potential
- History of radiotherapy to the head and neck area
- Presence of metastatic disease
- History of other malignancy within the last 3 years (except treated in-situ cervix carcinoma and non-melanoma skin carcinoma)
- Participation in another clinical study that may interfere with this study
- Pregnant or lactating women
- Assessed by investigator as unable or unwilling to comply with protocol requirements
- Patient deprived of freedom or under guardianship
AI-Screening
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Trial Site Locations
Total: 25 locations
1
Chu Amiens
Amiens, France
Not Yet Recruiting
2
Institut de Cancérologie de l'Ouest
Angers, France
Not Yet Recruiting
3
Centre François Baclesse
Caen, France
Actively Recruiting
4
CHU CAEN
Caen, France
Not Yet Recruiting
5
Centre Jean Perrin
Clermont-Ferrand, France
Not Yet Recruiting
6
CHIC
Créteil, France
Not Yet Recruiting
7
Centre Georges-François Leclerc
Dijon, France
Not Yet Recruiting
8
Centre Guillaume le Conquérant
Le Havre, France
Not Yet Recruiting
9
Centre Hospitalier
Libourne, France
Not Yet Recruiting
10
Centre Oscar Lambret
Lille, France
Not Yet Recruiting
11
Centre Léon Bérard
Lyon, France
Not Yet Recruiting
12
APHM Marseille
Marseille, France
Not Yet Recruiting
13
Institut Régional du Cancer Val D'aurelle
Montpellier, France
Not Yet Recruiting
14
Institut de Cancérologie de Lorraine
Nancy, France
Not Yet Recruiting
15
Centre Antoine Lacassagne
Nice, France
Not Yet Recruiting
16
APHP La Pitié
Paris, France
Not Yet Recruiting
17
Chu Poitiers
Poitiers, France
Not Yet Recruiting
18
Institut Jean Godinot
Reims, France
Not Yet Recruiting
19
Centre Eugène Marquis
Rennes, France
Not Yet Recruiting
20
Centre Henri Becquerel
Rouen, France
Not Yet Recruiting
21
Chu Rouen
Rouen, France
Not Yet Recruiting
22
Institut de Cancérologie de l'Ouest
Saint-Herblain, France
Not Yet Recruiting
23
IUCT
Toulouse, France
Not Yet Recruiting
24
Chu Tours
Tours, France
Not Yet Recruiting
25
Institut Gustave Roussy
Villejuif, France
Not Yet Recruiting
Research Team
J
Juliette THARIAT, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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