Actively Recruiting
Flemish Joint Effort for Biomarker PRofiling in Inflammatory Systemic Diseases
Led by University Hospital, Ghent · Updated on 2024-09-19
2500
Participants Needed
7
Research Sites
378 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Ghent
Lead Sponsor
U
University Hospital, Antwerp
Collaborating Sponsor
AI-Summary
What this Trial Is About
A multi-centre, prospective study to study cytokine profiles and other potential disease-specific biomarkers in patients with presumed or confirmed diseases of systemic inflammation The goal of this prospective, observational study is to describe the longitudinal evolution of blood cytokine profiles in patients with presumed or confirmed diseases of systemic inflammation The main questions it aims to answer are: * What are the differences and similarities in blood cytokines between different patients and groups presenting symptoms of systemic inflammatory conditions? * How is the cytokine profile of individual patients evolving over time and what is the effect of different therapeutics? * Is cytokine profiling a valuable tool to diagnose and follow-up on patients with systemic inflammatory conditions? Participants will be asked to give an additional blood volume for research purposes when blood sampling is performed for routine clinical purposes. A subset of patients (those initiated on biologicals) will also be asked to complete questionnaires. Researchers will compare the blood cytokines profiles between the different groups of systemic inflammatory conditions and with healthy individuals.
CONDITIONS
Official Title
Flemish Joint Effort for Biomarker PRofiling in Inflammatory Systemic Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Child or adult
- Written informed consent
- Suspected or confirmed systemic inflammatory disease, including autoinflammatory diseases such as systemic onset juvenile idiopathic arthritis, familial Mediterranean fever, mevalonate kinase deficiency, TNF receptor-associated periodic syndrome, familial Cold Autoinflammatory Syndrome, type 1 interferonopathies
- Autoimmune diseases such as systemic lupus erythematosus, juvenile dermatomyositis, rheumatoid arthritis
- Hyperinflammatory diseases such as hemophagocytic lymphohistiocytosis, macrophage activation syndrome, infection-related cytokine storm
- Other unidentified or not yet identified systemic inflammatory conditions
- Planned blood sample for diagnostic purposes with possibility to collect additional blood for research
You will not qualify if you...
- Confirmed localized infection responding well to first-line antibiotic treatment
- Confirmed malignancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
UZ Antwerpen
Antwerp, Belgium
Actively Recruiting
2
ZNA
Antwerp, Belgium
Not Yet Recruiting
3
UZ Brussel
Brussels, Belgium
Actively Recruiting
4
Ghent University Hospital
Ghent, Belgium, 9000
Actively Recruiting
5
UGent
Ghent, Belgium
Active, Not Recruiting
6
Jessa Hospital
Hasselt, Belgium
Actively Recruiting
7
UHasselt
Hasselt, Belgium
Active, Not Recruiting
Research Team
F
Filomeen Haerynck
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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