Flexibility, Resistance, Aerobic, Movement Execution (FRAME) Training Program to Improve Gait Capacity in Adults With Hereditary Spastic Paraplegia: Protocol for a Single-cohort Feasibility Trial

What this Trial Is About

Hereditary Spastic Paraplegia (HSP) is a group of inherited neurological conditions causing progressive weakness and stiffness in the lower limbs, which greatly reduce walking ability and balance. This research aims to evaluate the feasibility and effectiveness of a structured training program designed to improve walking function in adults with HSP by focusing on flexibility, muscle strength, motor control, balance, and aerobic fitness. Participants will take part in 10 to 16 therapy sessions lasting between 60 and 120 minutes each, held once or twice a week according to individual preference. The program includes four key components: flexibility exercises combined with electrical stimulation to reduce muscle tone; resistance training targeting hip and trunk muscles along with balance exercises; motor control-based gait training; and high-intensity interval aerobic training using activities like walking or cycling. After completing the supervised sessions, participants will receive written and video materials to support continued exercise at home. Evaluations will be conducted before the program starts, immediately after it ends (5 to 10 weeks later), and three months after completion. Researchers will assess the feasibility by tracking recruitment, adherence to the sessions, participant retention, safety, and satisfaction. They will also measure changes in walking endurance and speed using standardized walking tests, as well as improvements in muscle strength, balance, and joint mobility.

Flexibility, Resistance, Aerobic, Movement Execution Training in Adults With Hereditary Spastic Paraplegia