Actively Recruiting

Phase 4
Age: 18Years +
All Genders
NCT05203172

The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials

Led by Pfizer · Updated on 2026-04-07

46

Participants Needed

67

Research Sites

369 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this clinical trial (called the FLOTILLA study) is to give continued access to the study medicines, as well as safety follow-up, for participants in prior clinical trials of encorafenib and/or binimetinib. All participants who took part in earlier encorafenib and/or binimetinib studies may participate the FLOTILLA study if they are still benefiting from the use of the study medicines. This will be determined by the study doctor. People may not participate in the FLOTILLA study if they have not enrolled in a prior study of encorafenib or binimetinib. Participants that had enrolled but had stopped receiving the study treatment in a prior study cannot enrolled in this study. Participants in the FLOTILLA study will receive encorafenib and/or binimetinib at the same dose and frequency as in their prior study, for up to about 5 years.

CONDITIONS

Official Title

The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Participants currently receiving encorafenib/binimetinib in a parent study and benefiting clinically, with no ongoing Grade 3 or higher or intolerable Grade 2 side effects related to treatment
  • Agreement to follow reproductive safety criteria outlined in the continuation sub-study protocol
Not Eligible

You will not qualify if you...

  • Any medical reason that the investigator or sponsor believes prevents participation in the study

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 67 locations

1

St. Joseph's Hospital and Medical Center

Phoenix, Arizona, United States, 85004

Actively Recruiting

2

St. Joseph's Hospital and Medical Center

Phoenix, Arizona, United States, 85013

Actively Recruiting

3

Emory University Hospital Midtown

Atlanta, Georgia, United States, 30308

Actively Recruiting

4

Emory University Hospital

Atlanta, Georgia, United States, 30322

Actively Recruiting

5

Investigational Drug Service Emory University Clinic

Atlanta, Georgia, United States, 30322

Actively Recruiting

6

Winship Cancer Institute of Emory University

Atlanta, Georgia, United States, 30322

Actively Recruiting

7

Massachusetts General Hospital

Boston, Massachusetts, United States, 02114

Actively Recruiting

8

HealthPartners Cancer Research Center

Saint Paul, Minnesota, United States, 55101

Actively Recruiting

9

Regions Hospital Pharmacy

Saint Paul, Minnesota, United States, 55101

Actively Recruiting

10

Siteman Cancer Center

St Louis, Missouri, United States, 63108

Actively Recruiting

11

Barnes-Jewish Hospital

St Louis, Missouri, United States, 63110

Actively Recruiting

12

Washington University School of Medicine

St Louis, Missouri, United States, 63110

Actively Recruiting

13

Washington University

St Louis, Missouri, United States, 63110

Actively Recruiting

14

MSK Basking Ridge

Basking Ridge, New Jersey, United States, 07920

Active, Not Recruiting

15

Rockefeller Outpatient Pavilion (53rd Street)

New York, New York, United States, 10022

Active, Not Recruiting

16

Memorial Sloan Kettering Cancer Center

New York, New York, United States, 10065

Active, Not Recruiting

17

Duke Cancer Center

Durham, North Carolina, United States, 27710

Actively Recruiting

18

Investigational Chemotherapy Service

Durham, North Carolina, United States, 27710

Actively Recruiting

19

Peter MacCallum Cancer Centre

Melbourne, Victoria, Australia, 3000

Actively Recruiting

20

Liga Norte Riograndense Contra o Câncer

Natal, Rio Grande do Norte, Brazil, 59062-000

Actively Recruiting

21

ONCOSITE - Centro de Pesquisa Clinica em Oncologia

Ijuí, Rio Grande do Sul, Brazil, 98700-000

Actively Recruiting

22

Fundação Pio XII - Hospital de Câncer de Barretos

Barretos, São Paulo, Brazil, 14.780-070

Actively Recruiting

23

BP - A Beneficencia Portuguesa de São Paulo

São Paulo, São Paulo, Brazil, 01321-001

Actively Recruiting

24

Real e Benemerita Associacao Portuguesa de Beneficencia

São Paulo, São Paulo, Brazil, 01323-030

Actively Recruiting

25

University Health Network

Toronto, Ontario, Canada, M5G 2C4

Actively Recruiting

26

Princess Margaret Cancer Centre

Toronto, Ontario, Canada, M5G 2M9

Actively Recruiting

27

Jewish General Hospital

Montreal, Quebec, Canada, H3T 1E2

Actively Recruiting

28

Vseobecna fakultni nemocnice v Praze

Prague, Praha 2, Czechia, 12808

Actively Recruiting

29

Hopital Claude Huriez - CHU de Lille

Lille, NORD, France, 59037

Active, Not Recruiting

30

Gustave Roussy

Villejuif, Val-de-marne, France, 94800

Active, Not Recruiting

31

Universitaetsklinikum Tuebingen

Tübingen, Baden-Wurttemberg, Germany, 72076

Active, Not Recruiting

32

Otto-von-Guericke-Universitat Magdeburg

Magdeburg, Saxony-Anhalt, Germany, 39120

Active, Not Recruiting

33

Charité Universitaetsmedizin Berlin - Campus Mitte

Berlin, Germany, 10117

Actively Recruiting

34

Debreceni Egyetem Klinikai Kozpont

Debrecen, Hungary, 4032

Actively Recruiting

35

Rambam Health Care Campus

Haifa, Northern District, Israel, 3109601

Actively Recruiting

36

Instituto Tumori Giovanni Paolo II

Bari, Apulia, Italy, 70124

Actively Recruiting

37

Istituto Nazionale Tumori Regina Elena

Rome, ROMA, Italy, 00144

Actively Recruiting

38

Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia

Candiolo, Torino, Italy, 10060

Actively Recruiting

39

Istituto Oncologico Veneto IRCCS

Padova, Veneto, Italy, 35128

Actively Recruiting

40

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola

Bologna, Italy, 40138

Actively Recruiting

41

Istituto Europeo di Oncologia IRCCS

Milan, Italy, 20141

Active, Not Recruiting

42

Istituto Nazionale Tumori IRCCS Fondazione Pascale

Naples, Italy, 80131

Actively Recruiting

43

Radboudumc

Nijmegen, Gelderland, Netherlands, 6525 GA

Actively Recruiting

44

Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL)

Amsterdam, North Holland, Netherlands, 1066 CX

Actively Recruiting

45

Isala, locatie Zwolle

Zwolle, Netherlands, 8025 AB

Active, Not Recruiting

46

Instituto Português de Oncologia de Lisboa Francisco Gentil

Lisbon, Lisbon District, Portugal, 1099-023

Actively Recruiting

47

Instituto Português de Oncologia do Porto Francisco Gentil, EPE

Porto, Portugal, 4200-072

Actively Recruiting

48

N.N.Petrov Research Institute of Oncology

Saint Petersburg, Sankt-Peterburg, Russia, 197758

Actively Recruiting

49

Fed State Budgetary Inst "N.N. Blokhin Med Center of Oncology" MHRF

Moscow, Russia, 115478

Actively Recruiting

50

N.N.Petrov Research Institute of Oncology

Saint Petersburg, Russia, 197758

Actively Recruiting

51

Narodny onkologicky ustav

Bratislava, Bratislava Region, Slovakia, 833 10

Active, Not Recruiting

52

Seoul National University Hospital

Seoul, Seoul-teukbyeolsi [seoul], South Korea, 03080

Actively Recruiting

53

Severance Hospital, Yonsei University Health System

Seoul, Seoul-teukbyeolsi [seoul], South Korea, 03722

Actively Recruiting

54

Samsung Medical Center

Seoul, Seoul-teukbyeolsi [seoul], South Korea, 06351

Actively Recruiting

55

CHUAC-Hospital Teresa Herrera

A Coruña, A Coruña [LA Coruña], Spain, 15006

Actively Recruiting

56

Institut Català d'Oncologia (ICO) - Badalona

Badalona, Barcelona [barcelona], Spain, 08916

Actively Recruiting

57

Hospital Universitari Vall d'Hebron

Barcelona, Barcelona [barcelona], Spain, 08035

Actively Recruiting

58

Hospital Clinic de Barcelona

Barcelona, Catalunya [cataluña], Spain, 08008

Actively Recruiting

59

Hospital Clínic de Barcelona

Barcelona, Catalunya [cataluña], Spain, 08036

Actively Recruiting

60

Hospital Universitario Arnau de Vilanova de Lleida

Lleida, Lleida [lérida], Spain, 25198

Actively Recruiting

61

Hospital Universitario Puerta de Hierro Majadahonda

Majadahonda, Madrid, Comunidad de, Spain, 28222

Actively Recruiting

62

Hospital Universitari Vall d'Hebron

Barcelona, Spain, 08035

Actively Recruiting

63

Hospital Universitario HM Sanchinarro

Madrid, Spain, 28050

Actively Recruiting

64

Hospital Regional Universitario de Malaga

Málaga, Spain, 29010

Actively Recruiting

65

H.R.U Málaga - Hospital General

Málaga, Spain, 29011

Actively Recruiting

66

Hospital Universitario Central de Asturias

Oviedo, Spain, 33011

Actively Recruiting

67

Lancashire Teaching Hospitals NHS Foundation Trust - Royal Preston Hospital

Preston, Lancashire, United Kingdom, PR2 9HT

Actively Recruiting

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Research Team

P

Pfizer CT.gov Call Center

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

5

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The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials | DecenTrialz