Actively Recruiting
FLudrocortisone Administration in Aneurysmal Subarachnoid Haemorrhage
Led by The George Institute · Updated on 2025-12-16
524
Participants Needed
16
Research Sites
259 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A multi-centre, prospective, blinded, randomised clinical trial of fludrocortisone compared with placebo in patients presenting with aneurysmal subarachnoid haemorrhage. The study aim is to determine if early administration of enteral fludrocortisone in aneurysmal subarachnoid haemorrhage reduce death and dependency at six months.
CONDITIONS
Official Title
FLudrocortisone Administration in Aneurysmal Subarachnoid Haemorrhage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosed with subarachnoid haemorrhage from an aneurysm confirmed on computed tomography angiography or digital subtraction angiography
- Aneurysm has been secured
- Hospital admission for aneurysmal subarachnoid haemorrhage within 96 hours
- Currently being treated in a critical care environment
You will not qualify if you...
- Unable to receive medications by mouth or feeding tube
- Current treatment with glucocorticoids or mineralocorticoids
- Previous allergic reaction to fludrocortisone
- History of heart, liver, or kidney failure
- High or low sodium levels in recent blood tests (sodium greater than 145 mmol/L or less than 125 mmol/L)
- Imminent or inevitable death
- Pregnancy (confirmed or suspected)
- Previous participation in this trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 16 locations
1
John Hunter Hospital
New Lambton Heights, New South Wales, Australia, 2042
Not Yet Recruiting
2
Nepean Hospital
Penrith, New South Wales, Australia, 2747
Actively Recruiting
3
Prince of Wales Hospital
Randwick, New South Wales, Australia, 2031
Not Yet Recruiting
4
Royal North Shore Hospital
St Leonards, New South Wales, Australia, 2065
Not Yet Recruiting
5
Westmead Hospital
Westmead, New South Wales, Australia, 2145
Not Yet Recruiting
6
Wollongong Hospital
Wollongong, New South Wales, Australia, 2521
Not Yet Recruiting
7
Royal Brisbane Women's Hospital
Brisbane, Queensland, Australia, 4029
Not Yet Recruiting
8
Gold Coast University Hospital
Gold Coast, Queensland, Australia, 4215
Actively Recruiting
9
Townsville Hospital
Townsville, Queensland, Australia, 4814
Not Yet Recruiting
10
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia, 4102
Not Yet Recruiting
11
Royal Hobart Hospital
Hobart, Tasmania, Australia, 7000
Not Yet Recruiting
12
Monash Medical Centre
Clayton, Victoria, Australia, 3168
Not Yet Recruiting
13
St Vincent's Hospital (Melbourne)
Fitzroy, Victoria, Australia, 3065
Not Yet Recruiting
14
The Alfred Hospital
Melbourne, Victoria, Australia, 3044
Not Yet Recruiting
15
Auckland City Hospital
Auckland, New Zealand, 1023
Not Yet Recruiting
16
Wellington Hospital
Wellington, New Zealand, 6011
Not Yet Recruiting
Research Team
J
Jeremy Cohen, MBBS
CONTACT
D
Dorrilyn Rajbhandari, BN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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