Actively Recruiting
Fluid Administration and Fluid Accumulation in the Intensive Care Unit (FLUID-ICU) - an International Inception Cohort Study
Led by Nordsjaellands Hospital · Updated on 2025-02-06
1000
Participants Needed
21
Research Sites
17 weeks
Total Duration
On this page
Sponsors
N
Nordsjaellands Hospital
Lead Sponsor
U
University of Copenhagen
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to describe fluid administration and accumulation in critically ill adult patients admitted to the intensive care unit (ICU). The study focuses on understanding how fluid is given and accumulates during the entire ICU stay, exploring risk factors, management, and how fluid accumulation relates to patient outcomes. It is an international inception cohort study including adults admitted acutely to the ICU. Participants are observed during a 14-day inception period chosen by each site, with no interventions applied. Data collected include all routinely available information on fluid administration and removal, including treatments like diuretics or renal replacement therapy. Patients are followed daily until ICU discharge or death for up to 28 days, with additional follow-up at 90 days after ICU admission. During the study, researchers will collect daily data on fluid accumulation, fluid removal, and use of life-support measures. They will measure how many patients develop fluid accumulation, how long it lasts, and treatments used to manage it. Outcomes such as days alive without life-support, days out of hospital, and mortality within 90 days are also assessed. The study provides detailed epidemiological data on fluid management in ICU patients over a period of up to 3 months.
CONDITIONS
Brief Title
Fluid Administration and Fluid Accumulation in the Intensive Care Unit
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Acute admission to the intensive care unit (ICU) during the 14-day inception period
- Adults aged 18 years or older
You will not qualify if you...
- Previous participation in the FLUID-ICU study
- Major burns covering 10% or more of body surface
AI-Screening
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Your Study Journey
Duration - Up to 14 days
Participants are screened for eligibility to participate in the trial.
1 to 2 visits depending on ICU admission timing
Duration - Up to 28 days or until ICU discharge or death
Participants are observed daily during their ICU stay to collect data on fluid administration and accumulation without active intervention.
Daily assessments while in ICU
Duration - Single follow-up at 90 days post ICU admission
Participants are followed up 90 days after ICU admission to assess longer-term outcomes including survival and hospital status.
1 follow-up visit (in-person or remote)
Trial Site Locations
Total: 21 locations
1
Deparment of Intensive care, Nordsjællands hospital
Hillerød, Hillerød, Denmark, 3400
Completed
2
Department of Intensive Care, Sygehus Sønderjylland Aabenraa
Aabenraa, Denmark
Not Yet Recruiting
3
Departmen of Intensive Care
Aalborg, Denmark, 9000
Active, Not Recruiting
4
Department of Intensive Care, University hospital Aarhus
Aarhus, Denmark
Not Yet Recruiting
5
Department of Intensive Care, Rigshospitalet 4131
Copenhagen, Denmark, 2100
Actively Recruiting
6
Department of Intensive Care, Bispebjerg
Copenhagen, Denmark, 7100
Actively Recruiting
7
Department of Intensive Care, Herlev Hospital
Herlev, Denmark, 2730
Completed
8
Department of Intensive Care, Regionshospital Gødstrup
Herning, Denmark, 7400
Active, Not Recruiting
9
Department of Intensive Care, Zealand University hospital
Køge, Denmark, 4600
Completed
10
Department of Intensive Care, Regionshospitalet Randers
Randers, Denmark, 8930
Active, Not Recruiting
11
Department of Intensive Care, University Hospital Zealand, Roskilde
Roskilde, Denmark
Completed
12
Department of Intensive Care, Tampere University Hospital
Tampere, Finland, 33520
Active, Not Recruiting
13
Department of Intensive Care, Landspitali National University Hospital of Iceland
Reykjavik, Iceland
Completed
14
Department of Anaesthesiology, Critical Care and Pain Tata Memorial Hospital, Mumbai.
Mumbai, India
Not Yet Recruiting
15
Department of Anaesthesia and Critical Care Vilnuis University Hospital Santariskiu Cinics, Vilnuis
Vilnius, Lithuania
Active, Not Recruiting
16
Department of Intensive Care Wellington Hospital (CCDHB), Newton, Wellington
Wellington, New Zealand
Completed
17
Department of Intensive Care, Stavanger University Hospital
Stavanger, Norway, 4068
Active, Not Recruiting
18
Hospital Clinic of Barcelona
Barcelona, Spain
Actively Recruiting
19
Helsingborg Hospital
Helsingborg, Sweden
Active, Not Recruiting
20
Department of Intensive Care, Inselspital
Bern, Switzerland
Completed
21
General Adult Intensive Care Unit, Critical Care Directorate University Hospital of Wales, Cardiff
Cardiff, United Kingdom
Not Yet Recruiting
Research Team
C
Clara Molin, MD, PhD student
M
Morten Bestle, Professor, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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