Study Comparing Albumin and Ringers Solution Effects on Plasma Volume and Heart Function During Laparoscopic Surgery

What this Trial Is About

Researchers are evaluating the plasma expanding effects of three different fluid challenge strategies during longer laparoscopic abdominal surgeries lasting over 90 minutes. The study includes 60 patients randomized into three groups to compare acetated Ringers, albumin 5%, and albumin 20% solutions. The goal is to understand how these fluid treatments affect blood volume and circulation using hemoglobin as an indicator. The study groups receive specific fluid boluses acetated Ringers at 4 mlkg body weight, albumin 5% at 4 mlkg, and albumin 20% at 1 mlkg. After the first bolus infusion during surgery, if cardiac output increases by 10%, a second bolus is given and further studied. Circulatory effects are monitored using a Cardio Q probe inserted into the esophagus, and blood samples are taken at several intervals before and after fluid infusions. Participants undergo various assessments including blood tests for hemoglobin, albumin, and colloid osmotic pressure before surgery and at multiple time points during surgery. Additional measurements include bioimpedance, urine osmolality, and arterial blood gases. Researchers measure plasma volume expansion as the primary outcome at 60 minutes after fluid bolus, along with secondary measures like stroke volume, blood pressure, heart rate, and biochemical markers. The study is expected to conclude by October 2026.

Fluid Challenge and Plasma Volume, During Surgery