Actively Recruiting
Fluid Challenge and Plasma Volume, During Surgery
Led by Joachim Zdolsek · Updated on 2026-04-30
60
Participants Needed
1
Research Sites
157 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A short bolus infusion of fluid, called "fluid challenge" is commonly recommended for fluid treatment during longer surgery. However a prolonged increase of the blood volume is a prerequisite to recommend the technique. The purpose with the study is to examine the plasma expanding effect of three different fluid challenge strategies (acetated Ringers 4 ml/kg body weight, albumin 5% 4 ml/kg body weight or albumin 20% 1 ml/kg body weight), using hemoglobin as a dilution indicator.
CONDITIONS
Official Title
Fluid Challenge and Plasma Volume, During Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written consent to participate in the study
- For women: relevant contraceptive use, menopausal status, or a negative pregnancy test
- ASA category I to III
- Scheduled laparoscopic abdominal surgery lasting at least 90 minutes
- Age between 18 and 85 years
You will not qualify if you...
- Known cardiac failure
- Age less than 18 or greater than 85 years
- Known allergy to albumin
- Extracellular hyperhydration or hypervolemia
- Kidney failure
- Pregnancy or planned pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Vrinnevi Hospital
Norrköping, Östergötland County, Sweden, 60379
Actively Recruiting
Research Team
R
Robert Svensson, MD
CONTACT
H
Hans Bahlmann, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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