Personalized Fluid and Blood Pressure Treatment for Adults with Sepsis in the Emergency Department

What this Trial Is About

Researchers are evaluating whether a personalized treatment approach can improve care for adults with sepsis in the emergency department. Sepsis is a serious condition caused by the bodys uncontrolled response to infection, which can lead to low blood pressure, organ failure, and death. This study aims to see if adjusting fluid and blood pressure medicine based on how the heart responds can provide safer and more effective care compared to the standard fluid treatment. Participants will be randomly assigned to one of two groups. In the personalized treatment group, fluids and vasopressors medicines that raise blood pressure are given based on heart response measured with a non-invasive monitor tracking stroke volume index. The standard care group will receive fluids according to current guidelines, typically 30 milliliters per kilogram of body weight, as decided by their doctor. Treatment and monitoring focus on the first three hours after study enrollment. During the study, researchers will monitor the amount of fluids given, timing and use of vasopressors, blood pressure and circulation response, signs of organ recovery or damage, length of hospital stay, and any side effects. Participants will be followed during hospitalization, which averages about two weeks. The main outcome measured is the volume of intravenous fluids given within the first three hours, along with various secondary outcomes related to organ function and recovery.

Fluid Management and Individualized Resuscitation in Sepsis