Effects of Different Fluid Management Strategies on Blood Loss, Inflammatory Response, and Major Organ Sequelae in Liver Transplantation

What this Trial Is About

Researchers are evaluating different fluid management strategies during liver transplantation to reduce bleeding and improve patient outcomes. Due to the complexity of liver transplant surgery and issues with abnormal blood clotting, patients often experience significant bleeding requiring blood transfusions. Excessive transfusion can lead to lung complications and affect recovery. This study aims to compare restrictive and liberal fluid infusion approaches and their effects on bleeding, inflammation, and organ function after surgery. The trial randomly assigns participants to one of two groups. The liberal group receives fluid management targeting a stroke volume variation (SVV) of less than 10%, while the restrictive group targets an SVV of less than 18%. The PiCCO cardiopulmonary volume monitor is used to guide fluid administration during surgery. Researchers will observe the impact of these strategies on blood loss and organ function, including the lungs and kidneys. Participants will be closely monitored throughout the liver transplant operation and up to postoperative day 1. Measurements include blood loss during surgery, inflammatory responses, and biomarkers indicating lung and kidney injury. The study also tracks clinical care and any postoperative complications affecting major organs. This approach aims to identify the most appropriate fluid management method to support recovery after liver transplantation.

Fluid Management Strategies on Blood Loss in Liver Transplantation