Coexistence of a fluid responsive state and venous congestion signals in critically ill patients: a multicenter observational proof-of-concept study.
Felipe Muñoz, Pablo Born, Mario Bruna...
https://pubmed.ncbi.nlm.nih.gov/38374167Actively Recruiting
Led by Bicetre Hospital · Updated on 2025-01-13
64
Participants Needed
3
Research Sites
4 weeks
Total Duration
B
Bicetre Hospital
Lead Sponsor
F
First Affiliated Hospital, Sun Yat-Sen University
Collaborating Sponsor
Fluid responsiveness is an important factor that helps guide fluid therapy in critically ill patients. This research aims to better understand the relationship between fluid responsiveness and venous congestion, a condition where excess fluid causes pressure in the veins and can lead to worse health outcomes. The study focuses on how these factors change over time after giving a standardized fluid challenge to patients in intensive care. Patients in the intensive care unit who are monitored for heart function and have a clinical decision to receive intravenous crystalloid fluid will be observed. The study groups include those whose cardiac index increases by 15% or more after the fluid challenge and those who do not show this increase. The main goal is to compare changes in venous congestion, measured by the VExUS score, between these two groups immediately after and one hour following the fluid challenge. Participants will be closely monitored with hemodynamic tools before and after fluid administration. Researchers will assess the VExUS score for venous congestion changes at baseline, after 15 minutes, and again one hour later. This will help understand how fluid responsiveness affects venous congestion over time. The study is observational and will last until July 2025, involving adult patients aged 18 to 99 years who are receiving fluid therapy in the ICU.
CONDITIONS
Fluid Responsiveness and Venous Congestion Evolution During Volume Expansion
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 hour post fluid challenge
Participants are observed during and after a fluid challenge to assess fluid responsiveness and venous congestion changes.
1 visit including assessments before, immediately after, and 1 hour after the fluid challenge
Total: 3 locations
1
First affiliated Hospital , Sun Yat-sen University
Guangzhou, Guangdong, China, 510080
Actively Recruiting
2
Longgang Central Hospital of Shenzhen
Shenzhen, Guangdong, China, 518116
Actively Recruiting
3
Bicetre Hospital
Paris, Val-de-Marne, France, 94270
Actively Recruiting
X
Xiang SI, MD
X
Xavier MONNET, MD.PhD.
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Have more questions? Get in touch with our team for quick support
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Felipe Muñoz, Pablo Born, Mario Bruna...
https://pubmed.ncbi.nlm.nih.gov/38374167Xavier Monnet, Rui Shi, Jean-Louis Teboul
https://pubmed.ncbi.nlm.nih.gov/35633423Antonio Messina, Lorenzo Calabrò, Luca Pugliese...
https://pubmed.ncbi.nlm.nih.gov/35729632Xavier Monnet, Manu L N G Malbrain, Michael R Pinsky
https://pubmed.ncbi.nlm.nih.gov/36323911Adrien Joseph, Matthieu Petit, Philippe Vignon...
https://pubmed.ncbi.nlm.nih.gov/38671461