Coexistence of a fluid responsive state and venous congestion signals in critically ill patients: a multicenter observational proof-of-concept study.
Felipe Muñoz, Pablo Born, Mario Bruna...
https://pubmed.ncbi.nlm.nih.gov/38374167/Actively Recruiting
Led by Bicetre Hospital · Updated on 2025-01-13
64
Participants Needed
3
Research Sites
4 weeks
Total Duration
Fluid responsiveness is an important factor that helps guide fluid therapy in critically ill patients. This research aims to better understand the relationship between fluid responsiveness and venous congestion, a condition where excess fluid causes pressure in the veins and can lead to worse health outcomes. The study focuses on how these factors change over time after giving a standardized fluid challenge to patients in intensive care. Patients in the intensive care unit who are monitored for heart function and have a clinical decision to receive intravenous crystalloid fluid will be observed. The study groups include those whose cardiac index increases by 15% or more after the fluid challenge and those who do not show this increase. The main goal is to compare changes in venous congestion, measured by the VExUS score, between these two groups immediately after and one hour following the fluid challenge. Participants will be closely monitored with hemodynamic tools before and after fluid administration. Researchers will assess the VExUS score for venous congestion changes at baseline, after 15 minutes, and again one hour later. This will help understand how fluid responsiveness affects venous congestion over time. The study is observational and will last until July 2025, involving adult patients aged 18 to 99 years who are receiving fluid therapy in the ICU.
CONDITIONS
Fluid Responsiveness and Venous Congestion Evolution During Volume Expansion
X
Xiang SI, MD
X
Xavier MONNET, MD.PhD.
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Bicetre Hospital
Lead Sponsor
First Affiliated Hospital, Sun Yat-Sen University
Collaborating Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 hour post fluid challenge
Participants are observed during and after a fluid challenge to assess fluid responsiveness and venous congestion changes.
1 visit including assessments before, immediately after, and 1 hour after the fluid challenge
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/36323911/Bicetre Hospital
Lead Sponsor
First Affiliated Hospital, Sun Yat-Sen University
Collaborating Sponsor