Actively Recruiting
Fluid Responsiveness and Venous Congestion Evolution During Volume Expansion
Led by Bicetre Hospital · Updated on 2025-01-13
64
Participants Needed
3
Research Sites
29 weeks
Total Duration
On this page
Sponsors
B
Bicetre Hospital
Lead Sponsor
F
First Affiliated Hospital, Sun Yat-Sen University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Fluid responsiveness is a critical determinant guiding fluid therapy in critically ill patients. However, excessive fluid administration can result in fluid overload, leading to venous congestion and worse clinical outcomes. Venous congestion, a marker of impaired fluid clearance, is increasingly recognized as a significant contributor to poor prognosis. Previous studies have demonstrated the coexistence of fluid responsiveness and venous congestion in critically ill patients. Notably, these studies were limited by the absence of fluid challenge-the gold standard for assessing fluid responsiveness-leaving the dynamic relationship between fluid responsiveness and venous congestion incompletely understood. This study aims to investigate the interplay and temporal evolution of fluid responsiveness and venous congestion following a standardized fluid challenge in critically ill patients.
CONDITIONS
Official Title
Fluid Responsiveness and Venous Congestion Evolution During Volume Expansion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 18 years
- Hospitalized in the intensive care unit (ICU)
- Hemodynamic monitoring in place, with a pulse wave contour analysis-derived estimation of cardiac output (either calibrated or uncalibrated)
- Decision made by clinicians to perform volume expansion through intravenous infusion of crystalloid fluid
You will not qualify if you...
- Pregnancy
- Refusal to participate by relatives of the patient or the patient himself
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
First affiliated Hospital , Sun Yat-sen University
Guangzhou, Guangdong, China, 510080
Actively Recruiting
2
Longgang Central Hospital of Shenzhen
Shenzhen, Guangdong, China, 518116
Actively Recruiting
3
Bicetre Hospital
Paris, Val-de-Marne, France, 94270
Actively Recruiting
Research Team
X
Xiang SI, MD
CONTACT
X
Xavier MONNET, MD.PhD.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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