Fluorescence Guided Laparoscopic-Endoscopic Cooperative Sentinel Lymph Node Navigation Surgery for Early Gastric Cancer A Multicenter Randomized Trial Evaluating Safety and Effectiveness Compared to D2 Gastrectomy

What this Trial Is About

Researchers are investigating treatments for early gastric cancer EGC, focusing on improving surgical methods to preserve stomach function and enhance quality of life. The study compares traditional radical gastrectomy with sentinel node navigation surgery SNNS, which allows limited lymph node removal and may support function-preserving gastrectomy. This research aims to establish the safety and effectiveness of SNNS and better understand postoperative outcomes in patients with EGC. The study involves two main surgical approaches. One group receives fluorescence-guided laparoscopic-endoscopic cooperative sentinel lymph node navigation surgery, which includes precise tumor localization and selective lymph node removal using a fluorescent dye. The other group undergoes laparoscopic D2 radical gastrectomy following established guidelines for extensive lymph node dissection. Preoperative scans and endoscopic techniques help define tumor location and guide surgery. Different surgical procedures are applied depending on prior treatments and tumor characteristics. Participants will be assessed through imaging, pathology exams, and clinical evaluations before, during, and after surgery. The study measures include disease-free survival at 3 and 5 years, overall survival, complication rates, operation details, and quality of life indicators such as gastric emptying and hospital stay length. Safety monitoring includes tracking mortality, reoperations, and hospital readmissions within 30 days. The study will follow participants for up to 5 years to evaluate long-term outcomes and costs associated with each surgical method.

Fluorescence Guided Laparoscopic-Endoscopic Cooperative Sentinel Lymph Node Navigation Surgery Strategy for Early Gastric Cancer（IDEAL Stage 2b）