Actively Recruiting
Fluorescent Intra-operative Tumor Margin Examination
Led by Kurt Weiss · Updated on 2026-02-20
110
Participants Needed
1
Research Sites
304 weeks
Total Duration
On this page
Sponsors
K
Kurt Weiss
Lead Sponsor
S
Stryker Nordic
Collaborating Sponsor
AI-Summary
What this Trial Is About
Tumor margin confirmation is important to confirming appropriate disease excision. Current standard of care is to take select margin samples to pathology for intra-operative readings. However, this is expensive, time consuming, and only assesses the margin contained within the specific sample. In prior work the investigators have determined that indocyanine green (ICG) is highly specific to the tumor bed when injected shortly before surgery. The investigators hypothesize that ICG will be able to accurately identify residual positive tumor margins during sarcoma excision procedures.
CONDITIONS
Official Title
Fluorescent Intra-operative Tumor Margin Examination
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients above the age of 18 with a primary musculoskeletal tumor indicated for surgical excision by a fellowship trained orthopaedic oncologist
- Surgical consent obtained prior to research consent
- Biopsy-confirmed primary soft tissue or bone tumor not previously excised with known risk of local or remote recurrence
You will not qualify if you...
- Patients below the age of 18
- Pregnancy or breastfeeding
- History of anaphylactic reaction to contrast media or fluorescein allergy
- Prior surgery local to the mass being excised
- Non- or minimally-recurrent masses such as osteochondroma
- Dialysis, renal failure, or uremia
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UPMC-Shadyside Hospital
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
B
Beata Krawczyk, krawbx@upmc.edu
CONTACT
K
Kurt Weiss, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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