Actively Recruiting
Fluorine-18-AlphaVBeta6-Binding Peptide Positron Emission Tomography in Metastatic Non-Small Cell Lung Cancer
Led by University of California, Davis · Updated on 2026-02-27
20
Participants Needed
1
Research Sites
224 weeks
Total Duration
On this page
Sponsors
U
University of California, Davis
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study investigates fluorine-18-AlphaVBeta6-BP (\[18F\]-αvβ6-BP) as a Positron Emission (PET) imaging agent in Non-Small Cell Lung Cancer (NSCLC) patients with brain metastases. Investigators hypothesize that \[18F\]-αvβ6-BP PET/Computed Tomography (CT) is a sensitive tool for disease assessment in patients with metastatic NSCLC, including those with brain metastases.
CONDITIONS
Official Title
Fluorine-18-AlphaVBeta6-Binding Peptide Positron Emission Tomography in Metastatic Non-Small Cell Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women age >18 years
- Biopsy proven NSCLC with brain metastases (treated or untreated)
- Life expectancy of ≥3 months as judged by treating physician
- Available archival tumor tissue; metastatic site tissue preferred
- Able to tolerate study procedures and remain still for 30-60 minutes per scan
- Willing and able to sign informed consent
- Planned additional cancer-directed therapy followed by standard re-staging imaging
- [18F]-FDG PET/CT within 21 days of enrollment
- MRI brain within 21 days of enrollment
- Eastern Cooperative Oncology Group Performance Status ≤ 2
- Glomerular filtration rate (GFR) ≥ 60
You will not qualify if you...
- Pregnant or lactating women
- Prisoners
- Concurrent malignancy with different histology that could affect imaging
- Patients exceeding PET/CT weight limits (>350 lbs)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The University of California Davis Comprehensive Cancer Center
Sacramento, California, United States, 95817
Actively Recruiting
Research Team
P
Principal Investigator
CONTACT
J
Julie L Sutcliffe
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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