Actively Recruiting
FMRI-neurofeedback in Depression
Led by Maastricht University Medical Center · Updated on 2025-03-24
120
Participants Needed
3
Research Sites
222 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Previous studies with fMRI-neurofeedback in depression have demonstrated a good safety profile and considerable symptom reduction. The goal of this clinical trial is to compare fMRI-neurofeedback plus standard care with standard care in patients with depression. Participants will either receive standard care, or standard care plus a fMRI neurofeedback training, consisting of 5 neurofeedback training sessions. Symptom severity will be assessed before, immediately after and 6 months after the intervention.
CONDITIONS
Official Title
FMRI-neurofeedback in Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of a depressive disorder (ICD-10: F32 or F33)
- Stable antidepressant medication for at least 4 weeks (single or combination treatment)
- Current depression with QIDS score of 17 or higher
- If needed, minimum entry score may be lowered to QIDS 13 (moderate depression level)
You will not qualify if you...
- MRI exclusion criteria such as cardiac pacemaker or certain metallic implants
- History of psychotic disorder, bipolar disorder, or psychotic depression
- Use of illegal drugs in the last 4 weeks
- Current excessive alcohol consumption interfering with daily life
- History of neurological disease affecting brain imaging (e.g., stroke, multiple sclerosis, brain tumor)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Mondriaan Zorggroep
Maastricht, Netherlands, 6226NB
Actively Recruiting
2
Maastricht University
Maastricht, Netherlands, 6229ER
Actively Recruiting
3
Maastricht UMC+
Maastricht, Netherlands, 6229HX
Actively Recruiting
Research Team
D
David E Linden, Prof.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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