Actively Recruiting
An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction
Led by University of Missouri-Columbia · Updated on 2025-10-28
30
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are studying the effects of clavulanic acid on smoking behavior in adults who smoke cigarettes. The study aims to see if clavulanic acid can reduce smoking compared to a placebo. This research involves adult smokers aged 18 to 65 years and uses brain imaging to explore how the drug affects brain responses related to smoking. Participants will be randomly assigned to receive either clavulanic acid or a placebo in oral capsule form. The treatment lasts for 4 days, with capsules taken twice daily. The study includes a phase where brain activity is measured using functional MRI while participants view smoking-related images and during resting states to assess changes in brain connectivity. Throughout the study, participants will be monitored for changes in smoking habits over 5 days and any side effects reported. They will undergo brain scans and complete assessments to measure brain responses to smoking cues. The study also includes safety monitoring with urine pregnancy tests for females and checks for adherence to tobacco and nicotine abstinence during participation.
CONDITIONS
Brief Title
An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction
Research Team
M
Madhura Athreya, MS
B
Brett E Froeliger, PhD
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
