Actively Recruiting
An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction
Led by University of Missouri-Columbia · Updated on 2025-10-28
30
Participants Needed
1
Research Sites
387 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research study is looking into the effects of clavulanic on smoking behavior in adult cigarette smokers. The primary study hypothesis is that, compared to placebo, clavulanic acid will reduce smoking over the course of the study.
CONDITIONS
Official Title
An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-65 years
- Fluent in English
- Functional vision (with corrective lenses if needed) to complete assessments and tasks
- Smoke more than 10 cigarettes per day for at least 2 years and have an expired carbon monoxide concentration of at least 10 ppm
- Female participants must provide a negative urine pregnancy test
- Agree to avoid all other tobacco and nicotine products during the study
You will not qualify if you...
- Allergy or sensitivity to clavulanic acid or antibiotics
- Past head injury or neurological disorders linked to MRI abnormalities, including dementia, mild cognitive impairment, brain tumors, epilepsy, Parkinson's disease, or demyelinating diseases
- Physical or intellectual disabilities affecting assessment completion
- Any contraindication to MRI
- Use of antidepressants effective for smoking cessation
- Untreated illness or serious medical condition
- Current or past psychosis
- Electroconvulsive therapy within the last 6 months
- Positive pregnancy test, currently breastfeeding, or blood alcohol concentration above 0.0
- Use of carbamazepine, nitroglycerin, or other hazardous medications with clavulanic acid within 14 days before participation
- Abnormal liver function based on specified enzyme levels
- Abnormal kidney function based on specified laboratory values
- Any other condition that may affect safety, compliance, or study result interpretation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Missouri - Columbia
Columbia, Missouri, United States, 65211
Actively Recruiting
Research Team
M
Madhura Athreya, MS
CONTACT
B
Brett E Froeliger, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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