Actively Recruiting
FMT for the Prevention of Infectious Complications in Patients With Moderately Severe and Severe Acute Pancreatitis
Led by Changhai Hospital · Updated on 2026-04-14
150
Participants Needed
12
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn whether fecal microbiota transplantation (FMT) works to prevent infections complications in patients in the late phase of moderately severe or severe acute pancreatitis.
CONDITIONS
Official Title
FMT for the Prevention of Infectious Complications in Patients With Moderately Severe and Severe Acute Pancreatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- Diagnosed with moderately severe or severe acute pancreatitis according to the Revised Atlanta Classification 2012 and a CT severity index score greater than 4
- Disease duration of 15 to 21 days
- Have a nasojejunal tube in place
- No absolute contraindications to fecal microbiota transplantation
- Voluntarily signed the written informed consent form
You will not qualify if you...
- Severe systemic infection at the time of enrollment
- Extra-intestinal organ infection requiring broad-spectrum antibiotics
- Intestinal obstruction, active gastrointestinal bleeding, intestinal perforation, fulminant colitis, or toxic megacolon
- Unable to tolerate enteral nutrition meeting 50% of caloric needs due to severe diarrhea, fibrotic intestinal stricture, severe gastrointestinal bleeding, or high-output intestinal fistula
- Pre-existing chronic organ dysfunction (heart, lung, liver, kidney, or blood system) before admission
- Multiple organ dysfunction syndrome lasting more than 2 weeks
- Active cancer
- Autoimmune disease or immunocompromised status including organ transplant, AIDS, or long-term immunosuppressant or hormone use
- Congenital or acquired immunodeficiency
- Pregnancy or breastfeeding
- Severe mental disorder
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 12 locations
1
The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine
Fuzhou, Fujian, China
Not Yet Recruiting
2
Quanzhou First Hospital, Fujian
Quanzhou, Fujian, China
Not Yet Recruiting
3
Guangdong Hospital of Traditional Chinese Medicine
Guangzhou, Guangdong, China
Not Yet Recruiting
4
Guangzhou Medical University Affiliated Panyu Central Hospital
Guangzhou, Guangdong, China
Not Yet Recruiting
5
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
Not Yet Recruiting
6
The Affiliated Qingyuan People's Hospital of Guangzhou Medical University
Qingyuan, Guangdong, China
Not Yet Recruiting
7
Affiliated Hospital of Guangdong Medical University
Zhanjiang, Guangdong, China
Not Yet Recruiting
8
Changhai Hospital
Shanghai, Shanghai Municipality, China
Actively Recruiting
9
Renji Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
Not Yet Recruiting
10
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
Not Yet Recruiting
11
Shanghai General Hospital
Shanghai, Shanghai Municipality, China
Not Yet Recruiting
12
Shanghai Tenth People's Hospital ,Tenth People's Hospital Affiliated to Tongji University)
Shanghai, Shanghai Municipality, China
Not Yet Recruiting
Research Team
X
Xiang yu Kong, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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