Actively Recruiting
Phase 2 Study of Focal Ablation Using Cryotherapy or High-Intensity Ultrasound for Men With Localized Prostate Cancer
Led by University of California, Davis · Updated on 2026-06-30
100
Participants Needed
1
Research Sites
30 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of focal ablation using focal cryotherapy or high intensity focused ultrasound HIFU for treating men with localized prostate cancer. This study aims to determine how well these focal therapies work, assess patient urinary and sexual function, quality of life one year after treatment, and evaluate safety. The trial is sponsored by the University of California, Davis, and focuses on men with clinically localized prostate cancer. Participants receive either focal cryotherapy, which destroys tumor cells by freezing them, or high intensity focused ultrasound that uses sound waves to generate heat and kill tumor cells. After the treatment, participants are followed up at 7 to 14 days and then periodically for up to three years to monitor outcomes. During the study, participants undergo prostate biopsies at year 1 and year 3 to check the pathologic outcome and monitor if further whole gland salvage treatment is needed. Researchers also measure urinary and sexual function, quality of life after one year, and monitor any adverse events approximately 7 to 14 days after treatment. The overall study participation lasts up to three years with regular follow-up visits to track safety and treatment effects.
CONDITIONS
Brief Title
Focal Ablation With Focal Cryotherapy or HIFU for the Treatment of Men With Localized Prostate Cancer
Research Team
O
Office of Clinical Research
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