Actively Recruiting
The Food Environment, Microbial Cysteine Metabolism, and Cancer Disparities
Led by Purdue University · Updated on 2026-05-14
40
Participants Needed
2
Research Sites
119 weeks
Total Duration
On this page
Sponsors
P
Purdue University
Lead Sponsor
A
American Cancer Society, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if changing cysteine levels in the diet can influence how the body processes cysteine in Black and White individuals aged 45-75 with a history of non-cancerous polyps. The main questions it aims to answer are: * At the beginning of the study, do Black participants have higher levels of cortisol (a stress hormone) and compounds made from cysteine in their blood when compared to White participants? * Does eating less cysteine lower the body's natural cysteine activity and lead to less gut bacteria that break down cysteine? * Does eating less cysteine lead to less inflammation in the gut and lower levels of markers of inflammation in the blood? Research will compare a high cysteine diet and a low cysteine diet, and each participant will eat both diets. Participants will be in the study for 11 weeks and 2 days. Over the course of the study, participants will: * Eat a high cysteine diet for 3 weeks, and a low cysteine diet for 3 weeks * Eat a moderate cysteine diet for 1 week before each study diet * Complete surveys * Provide blood, stool, and saliva samples * Maintain food logs
CONDITIONS
Official Title
The Food Environment, Microbial Cysteine Metabolism, and Cancer Disparities
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 45 to 75 years
- Up to date with colorectal cancer screening colonoscopy and at high risk for colorectal cancer, defined as a history of 3 or more adenomatous polyps or an adenomatous polyp larger than 1 cm in the past 5 years
- Identify as Black or Non-Hispanic White
- If female, no menstrual period for at least six months
- Willingness to provide oral wash and stool samples
- Willingness to complete 24-hour dietary recalls
You will not qualify if you...
- Antibiotic use within the last 6 months
- Abnormal gastrointestinal transit
- History of organ transplantation
- Use of illicit drugs, combustible tobacco, or dietary supplements
- Use of pre- or probiotics within the last two months
- History of cancer treatment within the past 12 months
- Diagnosis of colorectal cancer or genetic predisposition to colorectal cancer
- Baseline body weight over 450 pounds
- Weight gain or loss greater than 4 kg within 3 months prior to study
- Significant food allergies, food preferences, or special therapeutic or vegetarian diets
- Menstrual cycle within the last 6 months
- Antibiotic use within the last 2 months
- Unable to keep a food record for 7 consecutive days during screening after instruction
- Significant medical conditions
- History of eating disorders
- Alcoholism
- Individuals under 18 years of age
AI-Screening
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Trial Site Locations
Total: 2 locations
1
University Hospital Clinical Research Center
Indianapolis, Indiana, United States, 46202
Not Yet Recruiting
2
Purdue Clinical Research Center
West Lafayette, Indiana, United States, 47906
Actively Recruiting
Research Team
P
Patricia G Wolf, PhD, RD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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