Actively Recruiting
Food Intake-Related Brain and Metabolic Responses in Obesity
Led by The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Updated on 2026-02-06
60
Participants Needed
1
Research Sites
88 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a prospective, single-center, randomized, controlled, crossover intervention trial. A total of 60 participants, including 30 patients with obesity and 30 healthy controls, will be enrolled. Each participant will receive an isocaloric liquid meal challenge (glucose, fat, or protein) on three separate experimental days, with a washout period of at least 7 days between visits to eliminate carryover effects from the previous intervention. The primary objective is to investigate the association between brain functional patterns and plasma metabolic profiles following the ingestion of different macronutrients in patients with obesity, aiming to uncover potential neuro-metabolic imbalance features.
CONDITIONS
Official Title
Food Intake-Related Brain and Metabolic Responses in Obesity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For obese participants: BMI of 28 kg/m2 or higher
- For healthy controls: BMI between 18.5 and 23.9 kg/m2
- Ages 18 to 40 years
- Any gender
- Right-handed individuals
You will not qualify if you...
- Diabetes mellitus
- Allergies or contraindications to any ingredients in the study meals
- Central nervous system or psychiatric disorders, or recent use of related medications
- Severe liver, kidney, heart, or gastrointestinal problems
- Contraindications to MRI such as implanted metal devices or claustrophobia
- Pregnancy or breastfeeding
- Current or recent participation in another clinical trial or use of nutritional supplements
- History of metabolic or bariatric surgery
- Recent use of antibiotics or probiotics
- Recent use of metabolism-affecting or weight loss medications
- Significant weight changes recently
- Unusual dietary habits, high alcohol intake, heavy smoking, or high coffee consumption
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Endocrinology, Endocrine and Metabolic Disease Medical Center,Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Nanjing, Jiangsu, China, China 210008
Actively Recruiting
Research Team
Y
Yan Bi
CONTACT
Z
Zhou Zhang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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