Using Forced Oscillometry to Measure Lung Function in Infants With Bronchopulmonary Dysplasia and Healthy Term Infants

What this Trial Is About

Researchers are evaluating the use of a non-invasive method called forced oscillometry technique FOT to measure lung function and airway mechanics in premature and term infants with bronchopulmonary dysplasia BPD. This study aims to establish normal lung function values in healthy term infants and to understand how infants with BPD respond to bronchodilator therapy, considering genetic factors that may influence treatment response. The study uses a device called tremoflo N-100 designed specifically for newborns and infants up to 2 years old. It measures lung function in a few minutes while the infant is sleeping by applying small pressure waves during normal breathing through a cushioned mask. Measurements are taken before and after bronchodilator therapy in infants with BPD. The study includes both preterm infants with BPD and healthy term infants without lung disease to collect comparative data. Participants will have lung function assessed using the FOT device while lying down and breathing normally. Measurements typically take less than 20 seconds and are repeated up to three times at each visit. Researchers will analyze lung mechanics before and after bronchodilator treatment to study airway obstruction and drug responsiveness. The study will also gather genetic information to explore variability in treatment effects. Participation involves outpatient visits and will continue until the infant is under 2 years of age.

Forced Oscillometry in Infants With Bronchopulmonary Dysplasia