Actively Recruiting
Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study
Led by University of Delaware · Updated on 2026-03-24
120
Participants Needed
1
Research Sites
225 weeks
Total Duration
On this page
Sponsors
U
University of Delaware
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI. This will be done during a 30-minute infusion of a saline solution containing 3% salt. One trial will be conducted with a salt sensing channel blocker and one trial without the salt sensing channel blocker. This will help to assess the role of a specific salt sensing channel in the brain. Salt sensitivity of BP will be assessed using 7-day dietary feeding where participants will be given food to consume for 7-days. Comparisons will be made between salt resistant (no change in blood pressure going from low to high salt diets) and salt sensitive adults (a change in blood pressure going from low to high salt diets). The investigators think the changes in MRI will be greater in salt sensitive compared to salt resistant subjects.
CONDITIONS
Official Title
Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than 40 years and less than 60 years
- Blood pressure between 100/60 mmHg and 140/90 mmHg
- Body mass index between 18.5 kg/m2 and 35 kg/m2
- Serum potassium level between 3.5 mmol/L and 5.5 mmol/L
- No history of cardiovascular, renal, metabolic, or neurological disease
You will not qualify if you...
- Age less than 40 years or greater than 60 years
- Blood pressure less than 100/60 mmHg or greater than 140/90 mmHg
- Body mass index less than 18.5 kg/m2 or greater than 30 kg/m2
- Serum potassium level less than 3.5 mmol/L or greater than 5.5 mmol/L
- Abnormal ECG
- History of cardiovascular, cancer, metabolic, respiratory, or renal disease
- Use of hormone replacement therapy
- Current tobacco or nicotine use
- Pregnant or nursing mothers
- Major brain injury (excluding concussions)
- Clinically diagnosed psychiatric or neurological disorder
- Clinically diagnosed anxiety or depression
- Use of psychiatric, neurological, anxiety, or depression medications
- Use of hypertension medications
- Sulfonamide drug allergy
- Contraindications to MRI such as implants or metal
- Claustrophobia
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Delaware
Newark, Delaware, United States, 19713
Actively Recruiting
Research Team
M
Megan Wenner, PhD
CONTACT
V
Virginia Nuckols, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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