Actively Recruiting
Frameless Stereotactic Radiosurgery for Intact Brain Metastases
Led by University of Chicago · Updated on 2025-12-29
166
Participants Needed
1
Research Sites
259 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a randomized study to determine if not treating planning target volume (PTV) margins during radiation therapy worsens progression free survival rates in patients with brain metastases.
CONDITIONS
Official Title
Frameless Stereotactic Radiosurgery for Intact Brain Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older with an ECOG Performance Status of 0 to 2 and life expectancy of at least 3 months
- Histologically confirmed systemic cancer with 1 to 5 brain metastases visible on contrast-enhanced MRI
- Brain lesions must be well-defined and measurable, with maximum tumor diameter of 3.0 cm or less
- At least one lesion measuring 1.0 cm or larger and 0.5 cm or larger in the perpendicular diameter
- Negative pregnancy test within 14 days before CT simulation for women who can become pregnant
- Ability to understand and willing to sign informed consent
You will not qualify if you...
- Diagnosis of germ cell tumor, small cell carcinoma, or blood cancers
- Brain metastases located in the brain stem, midbrain, pons, medulla, or within 7 mm of optic nerves or pathways
- Leptomeningeal disease diagnosis
- Cranial radiotherapy within 90 days before enrollment or prior stereotactic radiosurgery to treated lesions
- Chemotherapy or immunotherapy within 14 days before stereotactic radiosurgery; hormonal therapy allowed
- For Her2-positive breast cancer, no anti-Her2 therapy within 14 days before stereotactic radiosurgery; no trastuzumab emtansine planned after radiosurgery
- Contraindications to gadolinium MRI such as incompatible pacemaker, severe kidney impairment, or gadolinium allergy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
Research Team
R
Robyn Hseu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here