Actively Recruiting
Free From Maintenance Drug Therapy in Multiple Myeloma (The FREEDMM Trial) for Minimal Residual Disease (MRD
Led by University of Illinois at Chicago · Updated on 2025-12-18
50
Participants Needed
1
Research Sites
365 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A pilot study to assess the risk of progression after stopping post-autologous stem cell transplant (ASCT) maintenance therapy in Minimal Residual Disease (MRD)-negative MM patients.
CONDITIONS
Official Title
Free From Maintenance Drug Therapy in Multiple Myeloma (The FREEDMM Trial) for Minimal Residual Disease (MRD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ECOG Performance Status equal to or less than 2 within 30 days prior to registration
- Revised International Staging System (R-ISS) stage I, 2, or 3
- Diagnosis of Multiple Myeloma as defined by International Myeloma Working Group (IMWG)
- Completed at least 2 years of post-autologous stem cell transplant (ASCT) maintenance therapy
- Maintenance therapy includes any anti-myeloma treatment started after ASCT to prevent recurrence (e.g., lenalidomide, bortezomib, RVD)
- Disease response is very good partial response (VGPR) or complete response (CR) at enrollment by IMWG criteria
- Ability to understand and sign informed consent or have a legally authorized representative to do so
You will not qualify if you...
- Diagnosis of plasma cell leukemia, AL amyloidosis, or POEMS syndrome
- Prior organ transplant or conditions requiring immunosuppressive therapy
- Previous allogeneic hematopoietic cell transplant
- Treatment with any investigational drug within 30 days before enrollment
- Unable to sign informed consent or lack of legally authorized representative
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Illinois Cancer Center
Chicago, Illinois, United States, 60612
Actively Recruiting
Research Team
K
Karen Sweiss, PharmD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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