Comparison of Freeze-dried Bone Allograft and Autogenous Bone Blocks in the Surgical Reconstruction of Horizontally Atrophied Jaws for Implant Placement: Randomized Clinical Trial

What this Trial Is About

Researchers are investigating bone augmentation techniques to improve dental implant success in patients with severe bone loss in the jaw after tooth loss. The study compares two types of bone graft materials: freeze-dried bone allograft blocks and autologous bone blocks harvested from the patient's own mandible. The goal is to evaluate which method better supports bone regeneration and implant rehabilitation by examining bone quality and implant outcomes. Participants will undergo lateral jaw augmentation surgery using either a freeze-dried bone allograft block or an autologous bone block. Both procedures involve local anesthesia, incisions to prepare the surgical site, and fixation of the bone blocks with screws. After surgery, patients receive antibiotics and anti-inflammatory medication. Three months after augmentation, dental implants are placed non-submerged into the augmented bone, and bone core biopsies are taken for detailed analysis. Fixed dental prostheses are delivered three months following implant placement. Throughout the study, participants will have cone beam computed tomography (CBCT) scans before and after augmentation to assess bone changes. Researchers will conduct histomorphometric and microCT analyses on bone samples to measure bone volume and quality. The primary outcomes include the success of bone augmentation and dental implants within three months and the success of implant-supported prostheses over five years. Participants are monitored closely with follow-up visits to evaluate healing and implant function.

Freeze-dried Bone Allograft vs Autologous Bone Blocks in the Lateral Augmentation of the Jaws