Actively Recruiting
Freeze-dried Bone Allograft vs Autologous Bone Blocks in the Lateral Augmentation of the Jaws
Led by Semmelweis University · Updated on 2025-10-03
30
Participants Needed
1
Research Sites
413 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
After tooth loss, the alveolar ridge undergoes various modeling and remodeling processes, resulting in overall bone resorption. In case of extensive alveolar atrophy, bone volume must be restored before or during implant placement to achieve successful dental rehabilitation and maximize implant survival and success rates. One possible method for reconstructing severe bone resorption is block bone augmentation. Due to its biological properties, autologous bone is considered the "gold standard" among bone graft materials, as it possesses osteoinductive, osteoconductive, and osteogenic properties. The advantages of using allografts over autologous bone grafts include reduced postoperative morbidity, decreased surgical time, and the absence of anatomical limitations regarding the amount of bone that can be harvested. The disadvantage of allografts is the loss of viable osteogenic cells and osteoinductive factors during processing. The aim of the study is: * to compare the success of the bone augmentation surgery depending on whether freeze-dried bone allograft blocks or autologous bone blocks are used, * compare the microarchitecture of the augmented bone depending on the bone graft material applied, * to evaluate the success of dental implants placed in the augmented bone and that of the prostheses delivered on the dental implants.
CONDITIONS
Official Title
Freeze-dried Bone Allograft vs Autologous Bone Blocks in the Lateral Augmentation of the Jaws
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Over 18 years old
- Require lateral bone augmentation for implant rehabilitation
You will not qualify if you...
- Smoking
- Pregnancy
- Poor oral hygiene
- Failure to attend follow-up visits
- Therapeutic-dose irradiation to the head and neck region
- Local bone tumors, cysts, or inflammatory processes
- Decompensated systemic diseases contraindicating surgery
- Use of medications affecting bone metabolism such as steroids, bisphosphonates, RANKL inhibitor antibodies, or VEGF antagonists
- Psychiatric disorders contraindicating implant rehabilitation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Semmelweis University Department of Public Dental Health
Budapest, Hungary, Hungary, 1088
Actively Recruiting
Research Team
C
Csilla Szerencse, DMD, MDS
CONTACT
M
Márton Kivovics, DMD, MDS, PHD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here