Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07104370

Freeze-dried Bone Allograft vs Autologous Bone Blocks in the Lateral Augmentation of the Jaws

Led by Semmelweis University · Updated on 2025-10-03

30

Participants Needed

1

Research Sites

413 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

After tooth loss, the alveolar ridge undergoes various modeling and remodeling processes, resulting in overall bone resorption. In case of extensive alveolar atrophy, bone volume must be restored before or during implant placement to achieve successful dental rehabilitation and maximize implant survival and success rates. One possible method for reconstructing severe bone resorption is block bone augmentation. Due to its biological properties, autologous bone is considered the "gold standard" among bone graft materials, as it possesses osteoinductive, osteoconductive, and osteogenic properties. The advantages of using allografts over autologous bone grafts include reduced postoperative morbidity, decreased surgical time, and the absence of anatomical limitations regarding the amount of bone that can be harvested. The disadvantage of allografts is the loss of viable osteogenic cells and osteoinductive factors during processing. The aim of the study is: * to compare the success of the bone augmentation surgery depending on whether freeze-dried bone allograft blocks or autologous bone blocks are used, * compare the microarchitecture of the augmented bone depending on the bone graft material applied, * to evaluate the success of dental implants placed in the augmented bone and that of the prostheses delivered on the dental implants.

CONDITIONS

Official Title

Freeze-dried Bone Allograft vs Autologous Bone Blocks in the Lateral Augmentation of the Jaws

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Over 18 years old
  • Require lateral bone augmentation for implant rehabilitation
Not Eligible

You will not qualify if you...

  • Smoking
  • Pregnancy
  • Poor oral hygiene
  • Failure to attend follow-up visits
  • Therapeutic-dose irradiation to the head and neck region
  • Local bone tumors, cysts, or inflammatory processes
  • Decompensated systemic diseases contraindicating surgery
  • Use of medications affecting bone metabolism such as steroids, bisphosphonates, RANKL inhibitor antibodies, or VEGF antagonists
  • Psychiatric disorders contraindicating implant rehabilitation

AI-Screening

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Trial Site Locations

Total: 1 location

1

Semmelweis University Department of Public Dental Health

Budapest, Hungary, Hungary, 1088

Actively Recruiting

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Research Team

C

Csilla Szerencse, DMD, MDS

CONTACT

M

Márton Kivovics, DMD, MDS, PHD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Freeze-dried Bone Allograft vs Autologous Bone Blocks in the Lateral Augmentation of the Jaws | DecenTrialz