Actively Recruiting
French Registry for Monitoring Pregnancies for Multiple Sclerosis
Led by Hospices Civils de Lyon · Updated on 2026-01-05
1500
Participants Needed
48
Research Sites
887 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The influence of pregnancy on the course of multiple sclerosis (MS) has long been a controversial topic. After the publication of the first large prospective study of pregnancy and MS in 1998, counselling of women with MS has radically changed and many patients have been able to fulfill their desire of motherhood. However, there are still some challenges for the neurologist, who has to face old unanswered questions or new issues, regarding the use of disease modifying drugs (DMDs) in this period of life, effects on the short and long term outcome of the mother (in terms of relapses and disability) and the child, role of breast-feeding and locoregional analgesia. To set up a national prospective pregnancy registry for patients with MS, nested within the Observatoire Français de la Sclérose en Plaque (OFSEP) cohort, owing to a better knowledge of interactions between MS and pregnancy-related issues (pregnancy itself, locoregional analgesia, breastfeeding, impact of using or stopping DMDs on women/children…)
CONDITIONS
Official Title
French Registry for Monitoring Pregnancies for Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients eligible for the Observatoire Français de la Sclérose en Plaque (OFSEP) cohort, including definite multiple sclerosis diagnosed by McDonald criteria
- All clinical courses of MS, including single attack MS, relapsing-remitting MS, secondary progressive MS, and primary progressive MS
- Patients with Radiologically Isolated Syndromes (RIS), validated by the RIS expert group
- Patients with Clinically Isolated Syndromes (CIS)
- Patients with neuromyelitis optica (NMO) and NMO spectrum disorders, validated by the NOMADMUS expert group
- No age limit; patients under 18 may participate with parental consent
- Ongoing pregnancy at any gestational age; inclusion encouraged as soon as pregnancy is diagnosed
- Ability to give informed consent
- Ability to read and/or understand French
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Trial Site Locations
Total: 48 locations
1
Chu D'Amiens
Amiens, France, 80054
Actively Recruiting
2
Centre Hospitalier Annecy Genevois
Annecy, France, 74000
Actively Recruiting
3
Centre Hospitalier d'Avignon
Avignon, France, 84000
Actively Recruiting
4
Hopital Jean Minjoz
Besançon, France, 25030
Actively Recruiting
5
Hopital Pellegrin
Bordeaux, France, 33076
Actively Recruiting
6
Hôpital de Brive
Brive-la-Gaillarde, France, 19100
Actively Recruiting
7
Hôpital Neurologique Pierre Wertheimer
Bron, France, 69677
Actively Recruiting
8
Hopital Cote de Nacre
Caen, France, 14033
Actively Recruiting
9
Centre hospitalier Métropole Savoie
Chambéry, France, 73000
Actively Recruiting
10
Hopital Gabriel Montpied
Clermont-Ferrand, France, 63003
Actively Recruiting
11
Hopital Henri Mondor
Créteil, France, 94010
Actively Recruiting
12
Hopital Du Bocage
Dijon, France, 21079
Actively Recruiting
13
Ch Epinal
Épinal, France, 88000
Actively Recruiting
14
Hôpital Raymond Poincaré
Garches, France, 92380
Actively Recruiting
15
Centre hospitalier Joséphine Baker Gonesse
Gonesse, France, 95500
Actively Recruiting
16
Chu de Grenoble
Grenoble, France, 38043
Actively Recruiting
17
Centre Hospitalier de Versailles Hôpital Andre Mignot
Le Chesnay, France, 78157
Actively Recruiting
18
Hôpital St Vincent De Paul
Lille, France, 59020
Actively Recruiting
19
Chru de Lille
Lille, France, 59037
Actively Recruiting
20
Hopital Dupuytren
Limoges, France, 87042
Actively Recruiting
21
Cabinet médical Dr Philippe NEUSCHWANDER
Lyon, France, 69006
Actively Recruiting
22
Centre Hospitalier Saint Joseph Saint Luc
Lyon, France, 69007
Actively Recruiting
23
Cabinet médical Dr C. CORNUT-CHAUVINC
Lyon, France, 69008
Actively Recruiting
24
Hopital Timone Adultes
Marseille, France, 13385
Actively Recruiting
25
Hopital Gui de Chauliac
Montpellier, France, 34295
Actively Recruiting
26
Cabinet médical Dr L. GUILLOTON
Mornant, France, 69440
Actively Recruiting
27
Hôpital Central
Nancy, France, 54035
Actively Recruiting
28
Hopital Pasteur
Nice, France, 06001
Actively Recruiting
29
Hopital Caremeau
Nîmes, France, 30029
Actively Recruiting
30
Hôpital Paris Saint Joseph
Paris, France, 75014
Actively Recruiting
31
Fondation Rotschild
Paris, France, 75019
Actively Recruiting
32
Hôpital national des Quinze-Vingt.
Paris, France, 75571
Actively Recruiting
33
Hopital Pitie Salpetriere
Paris, France, 75651
Actively Recruiting
34
Chi Poissy Saint Germain En Laye
Poissy, France, 78303
Actively Recruiting
35
Chr La Miletrie
Poitiers, France, 86021
Actively Recruiting
36
Hopital Rene Dubos
Pontoise, France, 95300
Actively Recruiting
37
Hopital Pontchaillou
Rennes, France, 35033
Actively Recruiting
38
Hôpital Charles-Nicolle
Rouen, France, 76000
Actively Recruiting
39
Centre Hospitalier de Saint-Denis
Saint-Denis, France, 93200
Actively Recruiting
40
Hopital G. Et R. Laennec
Saint-Herblain, France, 44800
Actively Recruiting
41
Centre Hospitalier Mémorial
Saint-Lô, France, 50009
Actively Recruiting
42
Hopital Nord
Saint-Priest-en-Jarez, France, 42277
Actively Recruiting
43
Hopital Hautepierre
Strasbourg, France, 67098
Actively Recruiting
44
Hôpital Foch
Suresnes, France, 92151
Actively Recruiting
45
Hopital Purpan
Toulouse, France, 31059
Actively Recruiting
46
Chru de Tours Hopital Bretonneau
Tours, France, 37044
Actively Recruiting
47
Médipôle Lyon Villeurbanne
Villeurbanne, France, 69100
Actively Recruiting
48
Hopital P. Zobda-Quitman
Fort-de-France, Martinique, 97200
Actively Recruiting
Research Team
S
Sandra VUKUSIC, Prof.
CONTACT
R
Romain MARIGNIER, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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