Actively Recruiting
Frequency of Interrupting Sitting and Cognitive Function
Led by Maastricht University Medical Center · Updated on 2026-01-14
33
Participants Needed
1
Research Sites
77 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Rationale: Sedentary behavior (SB) has been associated with impaired cognitive function in elderly, and negatively impacts glucose metabolism. Interrupting sitting with physical activity (PA) bouts may exert beneficial effects on cognitive function via an improved glucose metabolism. Nevertheless, the impact of breaking up prolonged sitting with various frequencies of PA bouts remains unexplored in young sedentary adults. Moreover, we hypothesize that the pattern of the breaks modifies the effects. Thus, randomized controlled trials (RCTs) are highly needed to investigate the effects of interrupting sitting with different frequencies of PA on cognitive function and glucose metabolism. We now hypothesize that interrupting sitting with different frequencies of walking breaks differentially affects cognitive function and glucose metabolism. Objective: The aim is to investigate the effects of breaking up sitting with different frequencies of PA bouts on cognitive function and glucose metabolism in young sedentary adults. Study design: A randomised, controlled cross-over study will be performed, consisting of four interventions in a counterbalanced order: uninterrupted prolonged sitting, short breaks, moderate breaks, and long breaks. Intervention: Participants will complete four conditions in a randomized, counterbalanced order: sitting (uninterrupted prolonged sitting without any interruptions), short breaks (walk 1 minute every 10 minutes), moderate breaks (walk 3 minutes every 30 minutes), and long breaks (walk 27 minutes during the intervention). Each condition lasts 4.5 hours.
CONDITIONS
Official Title
Frequency of Interrupting Sitting and Cognitive Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women aged 18-35 years
- BMI between 18.5-24.9 kg/m2
- Sitting for an average of at least 9 hours per day
- Exercising less than 2 to 3 times per week
- Stable body weight (weight change less than 3 kg in past 3 months)
- Willing to attend four 6-hour laboratory visits
- No difficult cannulation
You will not qualify if you...
- Sitting less than an average of 9 hours per day
- Exercising more than 3 times per week
- Drug abuse
- Using medication for blood pressure, lipids, or glucose metabolism
- Pregnant females
AI-Screening
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Trial Site Locations
Total: 1 location
1
Nutrition and movement science
Maastricht, Netherlands
Actively Recruiting
Research Team
R
Renyan Ma
CONTACT
H
Hans Savelberg, Phd
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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