Actively Recruiting
A Frequency-Modulated Music Intervention to Enhance Cognitive Processing Therapy (CPT) for PTSD
Led by Ohio State University · Updated on 2026-02-03
100
Participants Needed
2
Research Sites
161 weeks
Total Duration
On this page
Sponsors
O
Ohio State University
Lead Sponsor
W
Wright-Patterson Air Force Base
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if the addition of frequency filtered music (Safe and Sound Protocol) to daily cognitive processing therapy improves effectiveness for reducing PTSD symptoms. The main questions it aims to answer are: * Does the addition of frequency filtered music reduce PTSD symptoms for patients receiving cognitive processing therapy for PTSD? * Does the addition of frequency filtered music to cognitive processing therapy improve stress physiology (arousal)? * Does improvement in physiological stress regulation help explain improvements in hyperarousal and PTSD symptoms? Researchers will compare the effects of a frequency filtered classical music playlist to an identical playlist without added filtering. Participants will be randomized to a music playlist. Participants will: * Receive 10 daily sessions of cognitive processing therapy * Listen to 15 minutes of music before their therapy sessions (2.5 hours music listening total). * Complete clinical interviews and questionnaires before, during, and up to 6 months after therapy. * Have their physiological arousal monitored during listening and therapy sessions * Wear a Fitbit device and complete smartphone surveys for 4 weeks
CONDITIONS
Official Title
A Frequency-Modulated Music Intervention to Enhance Cognitive Processing Therapy (CPT) for PTSD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 18 years of age
- Meets diagnostic criteria for PTSD or subthreshold PTSD with hyperarousal
- Able to move between sitting and standing without assistance
- Able to attend two weeks of daily in-person therapy sessions at Ohio State University or Wright-Patterson Air Force Base Medical Center
You will not qualify if you...
- Heart condition such as cardiac arrhythmia or pacemaker
- Allergy preventing wearing adhesive for up to 2 hours
- Insufficient English fluency to fully participate in psychotherapy
- Use of hearing aids
- Current or prior tinnitus (persistent ringing or noises in ears not caused by external sound)
- Severe traumatic brain injury
- Ongoing stressor or condition placing participant at risk for injury or poor outcome
- Inability to complete informed consent due to acute medical or psychiatric conditions such as intoxication, mania, or psychosis
AI-Screening
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Trial Site Locations
Total: 2 locations
1
The Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
2
Wright Patterson Air Force Base Mental Health Center
Dayton, Ohio, United States, 45433
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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