Actively Recruiting
Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers
Led by Hoffmann-La Roche · Updated on 2026-04-29
600
Participants Needed
45
Research Sites
129 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
For participation in this epidemiological study, a single-day visit at the study site is required. Participants will be recruited from Huntington Disease clinics, and they will be asked to answer questions regarding their demographics, including sex, age, race and ethnicity, and their medical and medication history. At the end of the visit, a blood sample will be drawn to allow testing with a sequencing assay that is specifically designed for phasing single nucleotide polymorphisms (SNPs) on the wild-type Huntington (wtHTT) and mutant Huntington (mHTT) alleles.
CONDITIONS
Official Title
Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed the Informed Consent Form (ICF)
- Aged 25 to 60 years inclusive at the time of signing the ICF
- Confirmed carrier of the Huntington Disease gene expansion mutation
- Confirmed Total Functional Capacity (TFC) score of 9 or higher and Total Motor Score (TMS) greater than 6 within 12 months before signing the ICF
- Able to tolerate blood draws
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 45 locations
1
Uab Medicine
Birmingham, Alabama, United States, 35294
Completed
2
Barrow Neurological Institute
Phoenix, Arizona, United States, 85013
Completed
3
University of California San Diego
La Jolla, California, United States, 92037-1337
Completed
4
University of California Davis Medical System
Sacramento, California, United States, 95817
Completed
5
CenExel Rocky Mountain Clinical Research, LLC
Englewood, Colorado, United States, 80113
Completed
6
University of South Florida
Tampa, Florida, United States, 33612
Actively Recruiting
7
Northwestern University
Chicago, Illinois, United States, 60611
Completed
8
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States, 52242
Completed
9
John Hopkins University School of Medicine
Baltimore, Maryland, United States, 21287
Completed
10
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Active, Not Recruiting
11
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
12
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212
Actively Recruiting
13
EvergreenHealth Investigational Drug Services
Kirkland, Washington, United States, 98034
Actively Recruiting
14
Hospital Britanico de Buenos Aires
Ciudad Autonoma Buenos Aires, Argentina, C1284AEB
Completed
15
Calvary Health Care Bethlehem
Caulfield South, New South Wales, Australia, 3162
Actively Recruiting
16
Westmead Hospital
Westmead, New South Wales, Australia, 2145
Actively Recruiting
17
Royal Melbourne Hospital
Parkville, Victoria, Australia, 3050
Actively Recruiting
18
Graylands Hospital
Mount Claremont, Western Australia, Australia, 6010
Actively Recruiting
19
University of Alberta
Edmonton, Alberta, Canada, T6G 2G3
Actively Recruiting
20
University of British Columbia Hospital
Vancouver, British Columbia, Canada, V6T 2B5
Actively Recruiting
21
Centricity Research
Halifax, Nova Scotia, Canada, B3S 1N2
Actively Recruiting
22
North York General Hospital
Toronto, Ontario, Canada, M2J 1V1
Actively Recruiting
23
McGill University
Montreal, Quebec, Canada, H3A 2B4
Actively Recruiting
24
Rigshospitalet, Hukommelsesklinikken
København Ø, Denmark, 2100
Actively Recruiting
25
Charité - Universitätsmed. Berlin, Klinik für Psychiatrie und Psychotherapie
Berlin, Germany, 10117
Actively Recruiting
26
St. Josef-Hospital, Neurologische Klinik der Ruhr-Uni
Bochum, Germany, 44791
Completed
27
Universitätsklinikum Erlangen, Abteilung Molekulare Neurologie
Erlangen, Germany, 91054
Actively Recruiting
28
Universitätsklinikum Ulm
Ulm, Germany, 89081
Actively Recruiting
29
Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Lombardy, Italy, 20133
Actively Recruiting
30
Universita Degli Studi Di Firenze
Florence, Tuscany, Italy, 50134
Actively Recruiting
31
Auckland DHB - Neurlogy Department
Auckland, New Zealand
Actively Recruiting
32
New Zealand Brain Research Institute
Christchurch, New Zealand, 8011
Completed
33
Wellington Hospital
Wellington, New Zealand, 6021
Actively Recruiting
34
Szpital Sw. Wojciecha
Gda?sk, Poland, 80-462
Actively Recruiting
35
Wojskowy Instytut Medycyny Lotniczej
Warsaw, Poland, 01-755
Actively Recruiting
36
Unidade Local de Saude de Santa Maria, E.P.E. - Hospital de Santa Maria
Lisbon, Portugal, 1649-035
Actively Recruiting
37
CNS - Campus Neurológico
Torres Vedras, Portugal, 2560-280
Completed
38
Hospital Universitario de Badajoz
Badajoz, Spain, 06080
Actively Recruiting
39
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain, 08041
Actively Recruiting
40
Hospital Universitario de Burgos. Servicio de Neurología
Burgos, Spain, 09006
Actively Recruiting
41
Hospital Ramon y Cajal
Madrid, Spain, 28034
Actively Recruiting
42
Birmingham and Solihull Mental Health Foundation NHS Trust
Birmingham, United Kingdom, B16 8PF
Actively Recruiting
43
Addenbrookes Hospital
Cambridge, United Kingdom, CB2 0QQ
Actively Recruiting
44
National Hospital For Neurology and Neurosurgery
London, United Kingdom, WC1N 3BG
Actively Recruiting
45
John Radcliffe Hospital
Oxford, United Kingdom, OX3 9DU
Actively Recruiting
Research Team
R
Reference Study ID Number: WE45491 https://forpatients.roche.com/
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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