Actively Recruiting
Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass
Led by University of Colorado, Denver · Updated on 2024-11-21
70
Participants Needed
1
Research Sites
240 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Autologous blood transfused at the end of cardiopulmonary bypass will reduce total blood loss 24 hours after surgery and improve mitochondrial oxygen delivery measured by plasma succinate levels. The study design is a prospective randomized interventional trial of transfusion of fresh autologous whole blood versus standard of care expectant management of bleeding during elective cardiac surgery.
CONDITIONS
Official Title
Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult subjects aged 18 to 90
- Able to provide informed consent
- Willing to accept autologous or allogenic blood transfusion
- Scheduled for elective cardiac surgery with cardiopulmonary bypass
You will not qualify if you...
- Received allogenic blood bank products within the previous 3 months
- Hemodynamically unstable defined as systolic blood pressure less than 90 mmHg with heart rate over 100 or requiring intravenous vasopressor medications
- Significant active infection or sepsis confirmed by positive blood or wound culture
- Hemoglobin level less than 7 g/dl
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Colorado Hospital
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
N
Nathan J Clendenen, M.D.
CONTACT
N
Nick Naughton, B.A
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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