Actively Recruiting
Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury
Led by VA Office of Research and Development · Updated on 2026-04-14
55
Participants Needed
1
Research Sites
201 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators hope to develop a treatment for suicidal ideation (SI), impulsivity and functional impairments (such as difficulties in social and work settings) that occur after a mild traumatic brain injury (mTBI). These conditions have been shown to be linked. The investigators are using a high-powered magnetic pulse, called intermittent theta burst stimulation (iTBS) applied to the head to see if it can improve these symptoms. The high-powered magnetic pulse causes certain cells in the brain to activate, which seems to strengthen connections between parts of the brain. The purpose of this research is to gather early information on the safety and effectiveness of iTBS provided to the front of the head for impulsivity, SI and functional deficits after mTBI. The investigators plan to use the data collected in this study to develop larger studies in the future. iTBS is FDA approved, but not for these specific symptoms, or in the specific location the investigators are placing it. The investigators are testing to see if its effective for the above conditions when applied to the front of the head.
CONDITIONS
Official Title
Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 22 and 65 years
- Ability to read and speak English
- Meets criteria for mild traumatic brain injury (mTBI) based on symptom classification
- Suicidal ideation rating (C-SSRS) greater than 1 within the past month
- History of impulsivity documented in medical records or a score above 20 on the negative urgency impulsivity scale
You will not qualify if you...
- Contraindications to iTBS such as epilepsy
- Contraindications to MRI such as claustrophobia or metal implants
- Active substance use disorder according to DSM-V
- History of moderate to severe traumatic brain injury
- History of non-traumatic brain injury like stroke, neurosurgery, or hemorrhage
- History of or current psychosis not caused by external factors
- Pregnancy
- Active, unstable medical conditions
- Within 12 weeks of major surgery or operation
- Within 1 year of traumatic brain injury
AI-Screening
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Trial Site Locations
Total: 1 location
1
Edward Hines Jr. VA Hospital, Hines, IL
Hines, Illinois, United States, 60141-3030
Actively Recruiting
Research Team
A
Alexandra L Aaronson, MD
CONTACT
I
Ibuola Kale
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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