Treatment Study Using Frontal Intermittent Theta Burst Stimulation to Reduce Impulsivity and Suicidal Thoughts in Veterans With Mild Traumatic Brain Injury

What this Trial Is About

Researchers are studying a treatment for suicidal thoughts, impulsivity, and difficulties in social and work functions following a mild traumatic brain injury mTBI in Veterans. These symptoms are linked, and the study aims to see if intermittent theta burst stimulation iTBS, a high-powered magnetic pulse applied to the front of the head, can improve these conditions. The goal is to gather early data on the safety and effects of this treatment, which is approved by the FDA but not yet for these specific symptoms or location. The trial compares active iTBS treatment to a placebo sham iTBS. The iTBS is delivered using specialized devices that stimulate the brain to promote connections between brain areas involved in impulsivity and suicidal thinking. This randomized, double-blinded study focuses on Veterans aged 22 to 65 with mTBI, impulsivity, and suicidal ideation. Treatment sessions occur over about two weeks. Participants will be assessed before, during, and after treatment using scales measuring social and occupational functioning and suicidal thoughts. Brain imaging will be done to examine changes in brain connectivity related to treatment. The main outcomes include treatment session completion rates and changes in functioning and suicidal ideation. Safety, tolerability, and feasibility of the treatment will also be monitored throughout the study.

Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury